Randomized trial of anger control training for adolescents with Tourette's syndrome and disruptive behavior.

Randomized trial of anger control training for adolescents with Tourette's syndrome and disruptive behavior.
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对患有妥瑞氏综合症和破坏性行为的青少年进行愤怒控制训练的随机试验。

DOI:
10.1097/chi.0b013e3181985050
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发表时间:
2009
影响因子:
13.3
通讯作者:
Scahill,Lawrence
Scahill,Lawrence
中科院分区:
医学1区
文献类型:
--
作者:
Sukhodolsky,DenisG;Vitulano,LawrenceA;Carroll,DeirdreH;McGuire,Joseph;Leckman,JamesF;Scahill,Lawrence

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目的:评价10次单独进行的愤怒控制训练(ACT)对Tourette综合征(TS)和破坏性行为青少年的疗效。方法:26例TS和高水平破坏性行为的受试者(24例男孩和2例女孩;平均年龄12.7岁,SD 0.88)随机分为ACT组和常规治疗组(TAU)。以父母评定的破坏行为评定量表和独立评估者评定的临床总体印象改善量表作为主要结局指标。所有随机化受试者完成终点评价,ACT组所有受试者完成3个月随访评价。ACT组的破坏性行为评定量表评分下降了52%,而TAU对照组下降了11%(p <0.001)。在临床总体印象改善量表上,独立评估者将ACT条件下的13名受试者中的9名(69%)评定为改善或非常改善,而TAU条件下的13名受试者中的2名(15%)(p <0.01)。ACT组破坏性行为的减少在3个月的随访中得到了很好的维持。CONCLUSIONSAnger控制训练似乎可以减少TS青少年的破坏性行为。需要更大规模的试验来证实这些结果。
OBJECTIVETo evaluate the efficacy of a 10-session individually administered anger control training (ACT) for adolescents with Tourette's syndrome (TS) and disruptive behavior.METHODTwenty-six subjects (24 boys and 2 girls; mean age 12.7 years, SD 0.88) with TS and high levels of disruptive behavior were randomly assigned to ACT or treatment-as-usual (TAU). The parent-rated Disruptive Behavior Rating Scale and the Clinical Global Impression—Improvement Scale rated by the independent evaluator were used as primary outcome measures.RESULTSAll randomized subjects completed end-point evaluation, and all subjects in the ACT group completed 3-month follow-up evaluation. The Disruptive Behavior Rating Scale score decreased by 52% in the ACT group compared with a decrease of 11% in the TAU control group (p < .001). On the Clinical Global Impression—Improvement Scale, the independent evaluator rated 9 (69%) of 13 subjects in the ACT condition as much improved or very much improved compared with 2 (15%) of 13 in the TAU condition (p < .01). This reduction of disruptive behavior in the ACT group was well maintained at 3-month follow-up.CONCLUSIONSAnger control training seems to reduce disruptive behavior in adolescents with TS. Larger trials are needed to confirm these results.
帕罗西汀治疗与妥瑞氏症相关的阵发性愤怒。
DOI: 10.4088/jcp.v59n1104
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