Renal transport of uric acid: evolving concepts and uncertainties.
Renal transport of uric acid: evolving concepts and uncertainties.
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DOI：
10.1053/j.ackd.2012.07.009
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发表时间：
2012-11
影响因子：
2.9
通讯作者：
Moe OW
中科院分区：
文献类型：
--
作者：
Bobulescu IA;Moe OW
除了作为代谢废物的作用外，尿酸还被认为是一种在人体生理学和病理生理学中具有多种功能的重要分子，并且可能与肾结石和痛风以外的人类疾病有关。尿酸稳态由尿酸产生、肠道分泌和肾脏排泄之间的平衡决定。肾脏是循环尿酸水平的重要调节器，可重新吸收约 90% 的过滤尿酸盐，同时负责排出全身尿酸的 60-70%。肾脏处理尿酸盐的缺陷是导致高尿酸血症和痛风的常见病理生理因素。尽管在过去十年中取得了巨大进展，但肾脏尿酸盐转运的分子机制仍不完全清楚。许多转运蛋白是尿酸盐处理的候选参与者，其中 URAT1 和 GLUT9 是迄今为止特征最好的。随着新研究揭示了这些转运蛋白的生理学、药物作用的重要性以及与人群尿酸水平的遗传关联，了解这些转运蛋白对于临床医生来说越来越重要。未来可能会出现专门作用于个体肾尿酸转运蛋白的新药，用于治疗高尿酸血症和痛风。
In addition to its role as a metabolic waste product, uric acid has been proposed to be an important molecule with multiple functions in human physiology and pathophysiology and may be linked to human diseases beyond nephrolithiasis and gout. Uric acid homeostasis is determined by the balance between production, intestinal secretion, and renal excretion. The kidney is an important regulator of circulating uric acid levels, by reabsorbing around 90% of filtered urate, while being responsible for 60–70% of total body uric acid excretion. Defective renal handling of urate is a frequent pathophysiologic factor underpinning hyperuricemia and gout. In spite of tremendous advances over the past decade, the molecular mechanisms of renal urate transport are still incompletely understood. Many transport proteins are candidate participants in urate handling, with URAT1 and GLUT9 being the best characterized to date. Understanding these transporters is increasingly important for the practicing clinician as new research unveils their physiology, importance in drug action, and genetic association with uric acid levels in human populations. The future may see the introduction of new drugs that specifically act on individual renal urate transporters for the treatment of hyperuricemia and gout.
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影响因子：
64.8
作者：
Enomoto, A;Kimura, H;Endou, H
通讯作者：
Endou, H
影响因子：
3.5
作者：
Ekaratanawong, S;Anzai, N;Endou, H
通讯作者：
Endou, H
DOI：
10.1073/pnas.78.11.6858
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
AMES, BN;CATHCART, R;HOCHSTEIN, P
通讯作者：
HOCHSTEIN, P
影响因子：
4.8
作者：
Anzai, Naohiko;Ichida, Kimiyoshi;Sakurai, Hiroyuki
通讯作者：
Sakurai, Hiroyuki
影响因子：
4.6
作者：
Eraly, Satish A.;Vallon, Volker;Nigam, Sanjay K.
通讯作者：
Nigam, Sanjay K.