CRMP1 and CRMP4 are required for proper orientation of dendrites of cerebral pyramidal neurons in the developing mouse brain
CRMP1 and CRMP4 are required for proper orientation of dendrites of cerebral pyramidal neurons in the developing mouse brain
复制标题
CRMP1 和 CRMP4 是发育中小鼠大脑中大脑锥体神经元树突正确定向所必需的
DOI：
10.1016/j.brainres.2016.11.003
复制
发表时间：
2017
期刊：
影响因子：
2.9
通讯作者：
Ohshima T
中科院分区：
文献类型：
--
作者：
Takaya R;Nagai J;Piao W. Niisato E;Nakabayashi T;Yamazaki Y;Nakamura F;Yamashita N;Kolattukudy P. Goshima Y;Ohshima T
神经回路的形成是大脑发育的关键过程。轴突导向分子、其受体和细胞内介质对于建立神经回路是重要的。溃缩蛋白反应介体蛋白（CRMPs）是已知的许多排斥性导向分子的细胞间介体。突变小鼠的研究表明CRMPs在树突发育中的作用。然而，CRMP介导的树突发育的分子机制仍有待阐明。在这项研究中，我们发现CRMP 4 −/−小鼠大脑皮层中第V层锥体神经元的基底树突（向更深侧延伸）的方向异常。此外，我们观察到严重的异常，这些神经元的基底树突的方向在CRMP 1和4的双重敲除，这表明这两个基因的冗余功能。在海马CA 1区锥体神经元顶树突近端分叉表型中也观察到冗余基因功能。这些结果表明，CRMP 1和CRMP 4调节大脑皮层中第V层神经元的基底树突的适当取向。
Neural circuit formation is a critical process in brain development. Axon guidance molecules, their receptors, and intracellular mediators are important to establish neural circuits. Collapsin response mediator proteins (CRMPs) are known intercellular mediators of a number of repulsive guidance molecules. Studies of mutant mice suggest roles of CRMPs in dendrite development. However, molecular mechanisms of CRMP-mediated dendritic development remain to elucidate. In this study, we show abnormal orientation of basal dendrites (extension to deeper side) of layer V pyramidal neurons in the cerebral cortex of CRMP4−/− mice. Moreover, we observed severe abnormality in orientation of the basal dendrites of these neurons in double knockout of CRMP1 and 4, suggesting redundant functions of these two genes. Redundant gene functions were also observed in proximal bifurcation phenotype in apical dendrites of hippocampal CA1 pyramidal neurons. These results indicate that CRMP1 and CRMP4 regulate proper orientation of the basal dendrites of layer V neurons in the cerebral cortex.
登录
查看更多内容
影响因子：
16.2
作者：
Feng, GP;Mellor, RH;Sanes, JR
通讯作者：
Sanes, JR
影响因子：
4
作者：
Schlomann, Uwe;Schwamborn, Jens C.;Pueschel, Andreas W.
通讯作者：
Pueschel, Andreas W.
DOI：
10.1523/jneurosci.5563-11.2012
发表时间：
2012-01
期刊：
The Journal of Neuroscience
影响因子：
--
作者：
N. Yamashita;T. Ohshima;F. Nakamura;Papachan Kolattukudy;J. Honnorat;K. Mikoshiba;Y. Goshima
通讯作者：
N. Yamashita;T. Ohshima;F. Nakamura;Papachan Kolattukudy;J. Honnorat;K. Mikoshiba;Y. Goshima
影响因子：
3.5
作者：
Bader, Verian;Tomppo, Liisa;Korth, Carsten
通讯作者：
Korth, Carsten