Reduced Child-Oriented Face Mirroring Brain Responses in Mothers With Opioid Use Disorder: An Exploratory Study.
Reduced Child-Oriented Face Mirroring Brain Responses in Mothers With Opioid Use Disorder: An Exploratory Study.
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DOI：
10.3389/fpsyg.2021.770093
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发表时间：
2021
影响因子：
3.8
通讯作者：
Ho SS
中科院分区：
文献类型：
--
作者：
Swain JE;Ho SS
虽然在过去十年中，美国孕妇中阿片类药物使用障碍（OUD）的患病率成倍增加，但已对患有OUD的围产期妇女进行丁丙诺啡治疗（BT），以降低反复渴望和戒断的风险。然而，母亲与OUD的母亲的行为和债券可能会改变作为潜在的母亲行为神经回路（MBN）是阿片类药物敏感。在调节啮齿动物的母性行为，如舔和梳理，一系列阿片类药物敏感的脑区功能连接，包括腹侧苍白球（VP）。在人类中，这些大脑区域与辅助运动区（SMA）相互作用以调节母性行为，并且在阿片类药物的作用下功能失调。目前还不清楚这些大脑区域如何对接受BT的母亲的孩子的情绪做出反应。在这项针对产后第一年内的22名母亲的功能性磁共振成像（fMRI）初步研究中，包括6名接受BT的母亲和16名作为对照组（CG）的非OUD母亲，我们设计了一个儿童面部镜像任务，在功能磁共振成像设置，以评估母亲的反应，自己的孩子和一个陌生的孩子的面部表情的图片，在移情镜像条件（加入）和非-镜像观察条件（观察）。在每种情况下，每个孩子的中性，模糊，痛苦和快乐的表情以随机顺序重复显示。在BT/OUD与CG之间，SMA在对自己孩子的移情镜像（加入）与非镜像（观察）期间的反应降低。在MBN，左VP，父母的敏感性的关键，有类似的赤字。这项研究概述了潜在的机制，调查赤字的风险与OUD母亲的实际母亲的敏感性和养育行为的神经反应，和潜在的干预目标，减少压力和增强母亲的行为和儿童的结果。
While the prevalence of opioid use disorder (OUD) among pregnant women has multiplied in the United States in the last decade, buprenorphine treatment (BT) for peripartum women with OUD has been administered to reduce risks of repeated cycles of craving and withdrawal. However, the maternal behavior and bonding in mothers with OUD may be altered as the underlying maternal behavior neurocircuit (MBN) is opioid sensitive. In the regulation of rodent maternal behaviors such as licking and grooming, a series of opioid-sensitive brain regions are functionally connected, including the ventral pallidum (VP). In humans, these brain regions, interact with the supplementary motor area (SMA) to regulate maternal behaviors and are functionally dysregulated by opioids. It is unclear how these brain regions respond to the emotions of their child for mothers receiving BT. In this functional magnetic resonance imaging (fMRI) pilot study in 22 mothers within the first postpartum year, including six mothers receiving BT and 16 non-OUD mothers as a comparison group (CG), we devised a child face mirroring task in fMRI settings to assess maternal responses to pictures of facial expressions of own child and an unknown child in an empathic mirroring condition (Join) and a non-mirroring observation condition (Observe). In each condition, faces of neutral, ambiguous, distressed, and joyful expressions of each child were repeatedly displayed in a random order. The response of SMA during empathic mirroring (Join) vs. non-mirroring (Observe) of own child was reduced among BT/OUD vs. CG. Within MBN, the left VP, critical for parental sensitivity, had a similar deficit. This study outlines potential mechanisms for investigating the risks of deficits in the neural responses to actual maternal sensitivity and parenting behavior in mothers with OUD, and potential targets for interventions that reduce stress and augment maternal behavior and child outcome.
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