Selected human leukocyte antigen class II polymorphisms and risk of adult glioma.
Selected human leukocyte antigen class II polymorphisms and risk of adult glioma.
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DOI：
10.1016/j.jneuroim.2010.11.005
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发表时间：
2011-04
影响因子：
3.3
通讯作者：
Brenner, Alina V.
中科院分区：
文献类型：
--
作者：
Bassig, Bryan A.;Inskip, Peter D.;Burdette, Laurie;Shapiro, William R.;Selker, Robert G.;Fine, Howard A.;Loeffler, Jay S.;Black, Peter M.;Dubrow, Robert;Brenner, Alina V.
很少有研究探讨人类白细胞抗原(HL A)基因多态性与成人胶质瘤的关系，特别是在II类基因座。我们在一项以医院为基础的大型病例对照研究中，使用非条件Logistic回归分析，评估了选定的人类白细胞抗原II类基因多态与成人脑胶质瘤的相关性。DQB1*06(OR=1.67，95%CI=1.17~2.39)和DRB1*13(OR=1.69，95%CI=1.08~2.64)等位基因与脑胶质瘤的发病风险呈负相关(OR=0.63，95%CI=0.43~0.93)。这些结果表明，DQB1*06、DQB1*05和DRB1*13等位基因在脑胶质瘤易感性中可能起作用。
Few studies have examined the relationship between human leukocyte antigen (HLA) polymorphisms and adult glioma, particularly at class II loci. We evaluated the association between selected HLA class II polymorphisms and adult glioma in a large, hospital-based case-control study, using unconditional logistic regression. DQB1*06 (OR=1.67, 95% CI=1.17–2.39) and DRB1*13 (OR=1.69, 95% CI=1.08–2.64) alleles were associated with an increased risk of glioma, while the DQB1*05 allele showed an inverse association (OR=0.63, 95% CI=0.43–0.93). These results, which were of borderline significance once controlled for the false discovery rate, suggest a potential role for the DQB1*06, DQB1*05, and DRB1*13 alleles in glioma susceptibility.
影响因子：
8.6
作者：
Wang, Xinran;Ouyang, Yijian;Dai, Hongjie
通讯作者：
Dai, Hongjie