Global, distinctive, and personal changes in molecular and microbial profiles by specific fibers in humans.
Global, distinctive, and personal changes in molecular and microbial profiles by specific fibers in humans.
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DOI：
10.1016/j.chom.2022.03.036
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发表时间：
2022-06-08
影响因子：
30.3
通讯作者：
Snyder, Michael P.
中科院分区：
文献类型：
--
作者：
Lancaster, Samuel M.;Lee-McMullen, Brittany;Abbott, Charles Wilbur;Quijada, Jeniffer V.;Hornburg, Daniel;Park, Heyjun;Perelman, Dalia;Peterson, Dylan J.;Tang, Michael;Robinson, Aaron;Ahadi, Sara;Contrepois, Kevin;Hung, Chia-Jui;Ashland, Melanie;McLaughlin, Tracey;Boonyanit, Anna;Horning, Aaron;Sonnenburg, Justin L.;Snyder, Michael P.
膳食纤维通过微生物群起作用，改善心血管健康、代谢紊乱和癌症预防。为了了解补充膳食纤维对健康的益处，我们调查了两种流行的纯化纤维，阿拉伯木聚糖(AX)和长链菊粉(LCI)，以及五种纤维的混合物。我们介绍了代谢组学、脂类组学、蛋白质组学、元基因组学、细胞因子小组的多组学特征，以及对健康和胰岛素抵抗参与者的临床测量。每种纤维都与纤维依赖的生化和微生物反应有关。AX的摄入与低密度脂蛋白的显著降低和胆汁酸的增加有关，有助于观察到的胆固醇降低。LCI与双歧杆菌的增加有关。然而，在最高剂量的LCI中，肝脏的丙氨酸氨基转移酶升高和炎症增加。这项研究深入了解了纤维补充的影响，提供了对纤维诱导胆固醇降低背后的机制的见解，并展示了单独的、纯化的纤维对微生物组的影响。Lancaster等人。直接测试两种高纯度纤维对广泛的临床和生化特征的影响。他们发现，阿拉伯木聚糖是Metamucil的一种常见纤维，通过产生胆汁酸来降低胆固醇。而菊粉，一种许多蔬菜中常见的纤维没有任何作用，而高剂量则会引起炎症。
Dietary fibers act through the microbiome and improve cardiovascular health, metabolic disorders and cancer prevention. To understand health benefits of dietary fiber supplementation we investigated two popular purified fibers, arabinoxylan (AX) and long-chain inulin (LCI), and a mixture of five fibers. We present multi-omic signatures of metabolomics, lipidomics, proteomics, metagenomics, a cytokine panel and clinical measurements on healthy and insulin resistant participants. Each fiber is associated with fiber-dependent biochemical and microbial responses. AX consumption associates with a significant reduction in LDL and an increase in bile acids, contributing to its observed cholesterol reduction. LCI is associated with an increase in Bifidobacterium. However, at the highest LCI dose there is increased inflammation and elevation in the liver enzyme alanine aminotransferase. This study yields insights into the effects of fiber supplementation, it provides insights into mechanisms behind fiber induced cholesterol reduction, and it shows effects of individual, purified fibers on the microbiome. Lancaster et al. directly test the effects of two highly purified fibers on extensive clinical and biochemical profiles. They found that arabinoxylan, a common fiber of Metamucil, reduced cholesterol through bile acid production. Whereas inulin, a common fiber of many vegetables had no effect, while high doses caused inflammation.
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影响因子：
1.9
作者：
EINARSSON, K
通讯作者：
EINARSSON, K
影响因子：
6.3
作者：
Giacco, R;Clemente, G;Riccardi, G
通讯作者：
Riccardi, G
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作者：
Blattmann P;Heusel M;Aebersold R
通讯作者：
Aebersold R
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作者：
Contrepois, Kevin;Mahmoudi, Salah;Snyder, Michael
通讯作者：
Snyder, Michael
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56.9
作者：
Falony, Gwen;Joossens, Marie;Raes, Jeroen
通讯作者：
Raes, Jeroen