HopAS1 recognition significantly contributes to Arabidopsis nonhost resistance to Pseudomonas syringae pathogens.
HopAS1 recognition significantly contributes to Arabidopsis nonhost resistance to Pseudomonas syringae pathogens.
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HopAS1 识别显着有助于拟南芥非宿主对丁香假单胞菌病原体的抗性。
DOI：
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发表时间：
2012
期刊：
影响因子：
9.4
通讯作者：
Jonathan D. G. Jones
中科院分区：
文献类型：
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作者：
K. Sohn;Simon B. Saucet;Christopher R. Clarke;B. Vinatzer;Heath E. O’Brien;D. Guttman;Jonathan D. G. Jones
·植物免疫是通过感知保守的微生物信号(称为病原体/微生物相关分子模式(P/MAMPs))或病原体分泌的特定效应物来激活的。然而，目前还不知道为什么大多数微生物在大多数植物物种中都是非致病的。·非寄主抗性(NHR)由多层天然免疫组成，保护植物免受绝大多数潜在致病微生物的侵袭。效应触发免疫(ETI)与小种特异性抗病有关。然而，ETI在NHR中的作用尚不清楚。·丁香假单胞菌。番茄(PTO)T1在番茄(Solanum Lycopsicum)中是致病的，而在拟南芥中是非致病的。在这里，我们证明，除了类型III分泌系统(T3SS)依赖的效应器(T3SE)avrRpt2，第二个PTO T1的T3SE，HopAS1，在非寄主拟南芥中触发ETI。·HopAS1广泛存在于丁香疫霉菌株中，参与番茄的致病作用，并在数量上是拟南芥NHR到PTO T1所必需的。值得注意的是，所有在拟南芥中致病的供试菌株都携带截短的HopAS1变体形式，这表明HopAS1触发的免疫在拟南芥对广泛的丁香疫霉菌株的NHR中发挥着重要作用。
• Plant immunity is activated by sensing either conserved microbial signatures, called pathogen/microbe-associated molecular patterns (P/MAMPs), or specific effectors secreted by pathogens. However, it is not known why most microbes are nonpathogenic in most plant species. • Nonhost resistance (NHR) consists of multiple layers of innate immunity and protects plants from the vast majority of potentially pathogenic microbes. Effector-triggered immunity (ETI) has been implicated in race-specific disease resistance. However, the role of ETI in NHR is unclear. • Pseudomonas syringae pv. tomato (Pto) T1 is pathogenic in tomato (Solanum lycopersicum) yet nonpathogenic in Arabidopsis. Here, we show that, in addition to the type III secretion system (T3SS)-dependent effector (T3SE) avrRpt2, a second T3SE of Pto T1, hopAS1, triggers ETI in nonhost Arabidopsis. • hopAS1 is broadly present in P. syringae strains, contributes to virulence in tomato, and is quantitatively required for Arabidopsis NHR to Pto T1. Strikingly, all tested P. syringae strains that are pathogenic in Arabidopsis carry truncated hopAS1 variants of forms, demonstrating that HopAS1-triggered immunity plays an important role in Arabidopsis NHR to a broad-range of P. syringae strains.
影响因子：
7.2
作者：
McNellis, TW;Mudgett, MB;Staskawicz, BJ
通讯作者：
Staskawicz, BJ