Compensatory mutations in predicted metal transporters modulate auxin conjugate responsiveness in Arabidopsis.
Compensatory mutations in predicted metal transporters modulate auxin conjugate responsiveness in Arabidopsis.
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DOI：
10.1534/g3.112.004655
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发表时间：
2013-01
期刊：
影响因子：
--
通讯作者：
Bartel B
中科院分区：
文献类型：
--
作者：
Rampey RA;Baldridge MT;Farrow DC;Bay SN;Bartel B
Levels of the phytohormone indole-3-acetic acid (IAA) can be altered by the formation and hydrolysis of IAA conjugates. The isolation and characterization of Arabidopsis thaliana mutants with reduced IAA-conjugate sensitivity and wild-type IAA responses is advancing the understanding of auxin homeostasis by uncovering the factors needed for conjugate metabolism. For example, the discovery that the IAA-Ala-resistant mutant iar1 is defective in a protein in the ZIP family of metal transporters uncovered a link between metal homeostasis and IAA-conjugate sensitivity. To uncover additional factors impacting auxin conjugate metabolism, we conducted a genetic modifier screen and isolated extragenic mutations that restored IAA-amino acid conjugate sensitivity to the iar1 mutant. One of these suppressor mutants is defective in a putative cation diffusion facilitator, MTP5 (At3g12100; formerly known as MTPc2). Loss of MTP5 function restored IAA conjugate sensitivity to iar1 but not to mutants defective in IAA-amino acid conjugate amidohydrolases. Our results are consistent with a model in which MTP5 and IAR1 transport metals in an antagonistic fashion to regulate metal homeostasis within the subcellular compartment in which the IAA-conjugate amidohydrolases reside, and support previous suggestions that the ion composition in this compartment influences hydrolase activity.
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DOI：
10.1073/pnas.0506958103
发表时间：
2006-04-25
影响因子：
11.1
作者：
Dunkley, TPJ;Hester, S;Lilley, KS
通讯作者：
Lilley, KS
影响因子：
4.4
作者：
BELL, CJ;ECKER, JR
通讯作者：
ECKER, JR
拟南芥金属耐受性蛋白 AtMTP3 在铁缺乏和锌过量供应条件下通过介导锌从芽中排除来维持金属平衡
影响因子：
7.2
作者：
Arrivault, Stephanie;Senger, Toralf;Kraemer, Ute
通讯作者：
Kraemer, Ute
影响因子：
7.2
作者：
Clough, SJ;Bent, AF
通讯作者：
Bent, AF
DOI：
10.1007/bf00331020
发表时间：
1986-01-01
期刊：
MOLECULAR AND GENERAL GENETICS
影响因子：
--
作者：
HAUGHN, GW;SOMERVILLE, C
通讯作者：
SOMERVILLE, C