Metabolic, gastrointestinal, and CNS neuropeptide effects of brain leptin administration in the rat.
Metabolic, gastrointestinal, and CNS neuropeptide effects of brain leptin administration in the rat.
复制标题
脑瘦素给药对大鼠的代谢、胃肠道和中枢神经系统神经肽的影响。
DOI：
10.1152/ajpregu.1999.276.5.r1425
复制
发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Schwartz,MW
中科院分区：
文献类型：
--
作者：
vanDijk,G;Seeley,RJ;Thiele,TE;Friedman,MI;Ji,H;Wilkinson,CW;Burn,P;Campfield,LA;Tenenbaum,R;Baskin,DG;Woods,SC;Schwartz,MW
为探讨脑内瘦素是否参与影响摄食、代谢和胃肠功能的神经肽能通路，将瘦素(3.5μg)每日注入大鼠第三脑室，连续3天。为了区分瘦素的直接作用和瘦素引起的厌食症的继发性作用，我们研究了随机输入食物的车辆大鼠和配对喂养瘦素治疗动物的大鼠。与对照组相比，瘦素治疗组和配对喂养组大鼠体重减轻(−分别为8%)，血浆甘油三酯水平升高(分别为142%和17%)，但配对喂养大鼠仅检测到血浆脂肪酸和酮类的增加(分别为132%和234%)。与自由喂养组相比，配对喂养可减少静息能量消耗(−15%)和胃肠道充盈(−50%)，但瘦素治疗不能减少这两项指标。与对照组相比，瘦素增加了下丘脑促肾上腺皮质激素释放激素(CRH；61%)和前阿片黑素皮质素(POMC；31%)的mRNA，但不减少神经肽Y的mRNA。这些结果表明，CNS瘦素通过激活下丘脑CRH和POMC途径来防止热量限制下的代谢/胃肠反应，并提高了对中枢瘦素注射的这些外周反应参与瘦素的厌氧作用的可能性。
To investigate whether brain leptin involves neuropeptidergic pathways influencing ingestion, metabolism, and gastrointestinal functioning, leptin (3.5 μg) was infused daily into the third cerebral ventricular of rats for 3 days. To distinguish between direct leptin effects and those secondary to leptin-induced anorexia, we studied vehicle-infused rats with food available ad libitum and those that were pair-fed to leptin-treated animals. Although body weight was comparably reduced (−8%) and plasma glycerol was comparably increased (142 and 17%, respectively) in leptin-treated and pair-fed animals relative to controls, increases in plasma fatty acids and ketones were only detected (132 and 234%, respectively) in pair-fed rats. Resting energy expenditure (−15%) and gastrointestinal fill (−50%) were reduced by pair-feeding relative to the ad libitum group, but they were not reduced by leptin treatment. Relative to controls, leptin increased hypothalamic mRNA for corticotropin-releasing hormone (CRH; 61%) and for proopiomelanocortin (POMC; 31%) but did not reduce mRNA for neuropeptide Y. These results suggest that CNS leptin prevents metabolic/gastrointestinal responses to caloric restriction by activating hypothalamic CRH- and POMC-containing pathways and raise the possibility that these peripheral responses to CNS leptin administration contribute to leptin’s anorexigenic action.
登录
查看更多内容
促肾上腺皮质激素释放因子参与控制食物摄入和能量消耗
影响因子：
5.2
作者：
D. Richard
通讯作者：
D. Richard
影响因子：
15.9
作者：
Schwartz, MW;Seeley, RJ;Baskin, DG
通讯作者：
Baskin, DG
脑室内推注瘦素对遗传性肥胖 fa/fa 大鼠的减肥效果：与瘦动物相比，敏感性降低
影响因子：
7.7
作者：
I. Cusin;F. Rohner;A. Stricker‐Krongrad;B. Jeanrenaud
通讯作者：
B. Jeanrenaud
瘦素和 GLP-1-(7-36) 酰胺的中枢输注对大鼠大脑中的 c-FLI 有不同的刺激作用。
DOI：
10.1152/ajpregu.1996.271.4.r1096
发表时间：
1996
期刊：
The American journal of physiology.
影响因子：
--
作者：
VanDijk,G;Thiele,TE;Donahey,JC;Campfield,LA;Smith,FJ;Burn,P;Bernstein,IL;Woods,SC;Seeley,RJ
通讯作者：
Seeley,RJ
影响因子：
4.8
作者：
M. Schwartz;A. Sipols;J. L. Marks;G. Sanacora;Jeffery D. White;A. Scheurink;S. Kahn;D. Baskin;S. Woods;D. Figlewicz
通讯作者：
M. Schwartz;A. Sipols;J. L. Marks;G. Sanacora;Jeffery D. White;A. Scheurink;S. Kahn;D. Baskin;S. Woods;D. Figlewicz