Genome-wide association study: new genetic insights into HBV/HCV-related hepatocellular carcinoma genomes
Genome-wide association study: new genetic insights into HBV/HCV-related hepatocellular carcinoma genomes
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全基因组关联研究：对 HBV/HCV 相关肝细胞癌基因组的新遗传学见解
DOI：
10.1080/00365521.2016.1245778
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发表时间：
2017-02
期刊：
影响因子：
--
通讯作者：
Xizhong Shen
中科院分区：
文献类型：
--
作者：
Hairong Zhu;Jian Wu;Xizhong Shen
肝细胞癌（HCC）是癌症相关死亡的第三大常见原因，在中国东南部和撒哈拉以南非洲等发展中国家发病率最高。主要致病因素可分为环境影响和遗传变异两大类，主要由乙型或丙型肝炎病毒（HBV和HCV）引起。慢性乙型肝炎和丙型肝炎（CHB和CHC）的地理患病率各不相同，HBV在发展中国家严重感染，HCV在发达国家流行。乙型或丙型肝炎病毒感染通过细胞免疫攻击，通过炎症机制对肝细胞造成损害。然而，肝细胞损伤如何发展为HCC仍知之甚少。随着全基因组关联研究（GWAS）技术的成熟，从CHB或CHC发展为HCC的特定基因突变已经被确定。此外，由于种群的不同，对这些变异的类似研究结果也各不相同。为了将来的临床应用，需要更多的功能性实验来证实这些基因突变在HBV/HCV和HCC之间相关性中的确切作用。
Abstract Hepatocellular carcinoma (HCC) is the third common cause of cancer-related death with highest prevalence in developing countries, such as Southeast China and Saharan African. The major pathogenic factors can be categorized into environmental effects and genetic variations, and it is mostly caused by hepatitis B or C virus (HBV and HCV). The geographic prevalence of chronic hepatitis B and C (CHB and CHC) varies, with HBV heavily-infected in developing countries and HCV prevalent in developed countries. The infection of either hepatitis virus B or C causes damage to the liver cells through cellular immune attack by the mechanism of inflammation. However, how liver cell injury progresses to HCC development is still poorly understood. Along with the maturation of genome-wide association study (GWAS) technology, the specific genetic mutations responsible for the progression from CHB or CHC to HCC have been identified. Moreover, the findings of similar studies for these variants are different from each other due to diverse populations. More functional experiments are warranted to confirm the precise roles of these genetic mutations in the correlations between HBV/HCV and HCC for the future clinical application.
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影响因子：
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影响因子：
25.7
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通讯作者：
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