No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations.
No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations.
复制标题
DOI：
10.1186/1471-2350-13-47
复制
发表时间：
2012-06-19
影响因子：
--
通讯作者：
Tokunaga K
中科院分区：
文献类型：
--
作者：
Sawai H;Nishida N;Mbarek H;Matsuda K;Mawatari Y;Yamaoka M;Hige S;Kang JH;Abe K;Mochida S;Watanabe M;Kurosaki M;Asahina Y;Izumi N;Honda M;Kaneko S;Tanaka E;Matsuura K;Itoh Y;Mita E;Korenaga M;Hino K;Murawaki Y;Hiasa Y;Ide T;Ito K;Sugiyama M;Ahn SH;Han KH;Park JY;Yuen MF;Nakamura Y;Tanaka Y;Mizokami M;Tokunaga K
最近的一项全基因组关联研究（GWAS）在5个独立的中国人群中对伴有和不伴有肝细胞癌（HCC）的慢性HBV（乙型肝炎病毒）携带者进行了研究，发现KIF1B中的一个SNP （rs17401966）与HCC易感性相关。在本研究中，共有580例hbv来源的HCC病例和1351例慢性乙型肝炎（CHB）或无症状携带者（ASC）被用于复制研究，以评估其他东亚人群中hbv来源的HCC与报道的关联。我们在日本队列（复制1:OR = 1.09, 95% CI = 0.82-1.43；复制2:OR = 0.79, 95% CI = 0.54-1.15）、韩国队列（复制3:OR = 0.95, 95% CI = 0.66-1.36）或香港中国队列（复制4:OR = 1.17, 95% CI = 0.79-1.75）中未发现rs17401966与HCC之间的任何关联。使用这些队列的荟萃分析也没有显示任何关联（P = 0.97）。没有复制队列显示rs17401966与hbv来源的HCC之间存在关联。这可能是由于日本人、韩国人和中国人的遗传多样性不同。其他原因可能是基因组信息和表现的表型之间的多变量相互作用的高度复杂性。为了阐明这些亚洲人群中HCC易感性的差异，需要更广泛的研究。
A recent genome-wide association study (GWAS) using chronic HBV (hepatitis B virus) carriers with and without hepatocellular carcinoma (HCC) in five independent Chinese populations found that one SNP (rs17401966) in KIF1B was associated with susceptibility to HCC. In the present study, a total of 580 HBV-derived HCC cases and 1351 individuals with chronic hepatitis B (CHB) or asymptomatic carrier (ASC) were used for replication studies in order to evaluate the reported association with HBV-derived HCC in other East Asian populations. We did not detect any associations between rs17401966 and HCC in the Japanese cohorts (replication 1: OR = 1.09, 95 % CI = 0.82-1.43; replication 2: OR = 0.79, 95 % CI = 0.54-1.15), in the Korean cohort (replication 3: OR = 0.95, 95 % CI = 0.66-1.36), or in the Hong Kong Chinese cohort (replication 4: OR = 1.17, 95 % CI = 0.79-1.75). Meta-analysis using these cohorts also did not show any associations with P = 0.97. None of the replication cohorts showed associations between rs17401966 and HBV-derived HCC. This may be due to differences in the genetic diversity among the Japanese, Korean and Chinese populations. Other reasons could be the high complexity of multivariate interactions between the genomic information and the phenotype that is manifesting. A much wider range of investigations is needed in order to elucidate the differences in HCC susceptibility among these Asian populations.
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DOI：
10.1093/jnci/djn243
发表时间：
2008-08-20
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Yang HI;Yeh SH;Chen PJ;Iloeje UH;Jen CL;Su J;Wang LY;Lu SN;You SL;Chen DS;Liaw YF;Chen CJ;REVEAL-HBV Study Group
通讯作者：
REVEAL-HBV Study Group
影响因子：
254.7
作者：
Parkin, DM;Bray, F;Pisani, P
通讯作者：
Pisani, P
影响因子：
56.9
作者：
Abdulla, Mahmood Ameen;Ahmed, Ikhlak;Zilfalil, Bin Alwi
通讯作者：
Zilfalil, Bin Alwi
影响因子：
3.7
作者：
Chan KY;Wong CM;Kwan JS;Lee JM;Cheung KW;Yuen MF;Lai CL;Poon RT;Sham PC;Ng IO
通讯作者：
Ng IO
影响因子：
30.8
作者：
Zhang, Hongxing;Zhai, Yun;Zhou, Gangqiao
通讯作者：
Zhou, Gangqiao