Systemic inflammation in chronic obstructive pulmonary disease: a population-based study.
Systemic inflammation in chronic obstructive pulmonary disease: a population-based study.
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DOI：
10.1186/1465-9921-11-63
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发表时间：
2010-05-25
影响因子：
5.8
通讯作者：
EPI-SCAN Steering Committee
中科院分区：
文献类型：
--
作者：
Garcia-Rio F;Miravitlles M;Soriano JB;Muñoz L;Duran-Tauleria E;Sánchez G;Sobradillo V;Ancochea J;EPI-SCAN Steering Committee
已在选定的COPD患者人群中描述了几种炎症生物标志物的循环水平升高，尽管对其基于人群的分布知之甚少。本研究的目的是比较稳定期COPD患者和健康受试者的几种全身生物标志物水平，并根据临床变量评估其分布。这是EPI-SCAN研究（40-80岁）参与者的横断面研究设计。排除患有与炎症过程相关的任何其他病症的受试者。COPD定义为使用支气管扩张剂后FEV 1/FVC < 0.70。参照组由无呼吸道症状、相关疾病或处方药物的非COPD受试者组成。受试者接受生活质量问卷调查、肺功能测定和6分钟步行试验。检测血清C反应蛋白（CRP）、肿瘤坏死因子（TNF）-α、白细胞介素（IL-6和IL-8）、α 1-抗胰蛋白酶、纤维蛋白原、白蛋白和亚硝酸盐/硝酸盐（NOx）。我们比较了324例COPD患者和110例参考受试者。在调整性别、年龄、BMI和烟草消费量后，COPD患者显示出更高的CRP水平（0.477 ± 0.023 vs 0.376 ± 0.041 log mg/L，p = 0.049），TNF-α（13.12 ± 0.59 vs. 10.47 ± 1.06 pg/mL，p = 0.033），IL-8（7.56 ± 0.63 vs. 3.57 ± 1.13 pg/ml; p = 0.033）和NOx（1.42 ± 0.01 vs. 1.36 ± 0.02 log nmol/l; p = 0.048）。COPD患者血清中某些生物标志物的浓度与病情严重程度相关，运动耐量与CRP、IL-6、IL-8、纤维蛋白原和白蛋白的浓度相关。我们的研究结果提供了基于人群的证据，表明COPD与低度全身性炎症独立相关，其炎症模式与健康受试者不同。
Elevated circulating levels of several inflammatory biomarkers have been described in selected patient populations with COPD, although less is known about their population-based distribution. The aims of this study were to compare the levels of several systemic biomarkers between stable COPD patients and healthy subjects from a population-based sample, and to assess their distribution according to clinical variables. This is a cross-sectional study design of participants in the EPI-SCAN study (40-80 years of age). Subjects with any other condition associated with an inflammatory process were excluded. COPD was defined as a post-bronchodilator FEV1/FVC < 0.70. The reference group was made of non-COPD subjects without respiratory symptoms, associated diseases or prescription of medication. Subjects were evaluated with quality-of-life questionnaires, spirometry and 6-minute walk tests. Serum C-reactive protein (CRP), tumor necrosis factor (TNF)-α, interleukins (IL-6 and IL-8), alpha1-antitrypsin, fibrinogen, albumin and nitrites/nitrates (NOx) were measured. We compared 324 COPD patients and 110 reference subjects. After adjusting for gender, age, BMI and tobacco consumption, COPD patients showed higher levels of CRP (0.477 ± 0.023 vs. 0.376 ± 0.041 log mg/L, p = 0.049), TNF-α (13.12 ± 0.59 vs. 10.47 ± 1.06 pg/mL, p = 0.033), IL-8 (7.56 ± 0.63 vs. 3.57 ± 1.13 pg/ml; p = 0.033) and NOx (1.42 ± 0.01 vs. 1.36 ± 0.02 log nmol/l; p = 0.048) than controls. In COPD patients, serum concentrations of some biomarkers were related to severity and their exercise tolerance was related to serum concentrations of CRP, IL-6, IL-8, fibrinogen and albumin. Our results provide population-based evidence that COPD is independently associated with low-grade systemic inflammation, with a different inflammatory pattern than that observed in healthy subjects.
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影响因子：
10
作者：
Broekhuizen, R;Wouters, EFM;Schols, AMWJ
通讯作者：
Schols, AMWJ
DOI：
10.1164/ajrccm.153.1.8542131
发表时间：
1996-01-01
影响因子：
24.7
作者：
Maltais, F;Simard, AA;Janvier, R
通讯作者：
Janvier, R
影响因子：
3.2
作者：
Franciosi, LG;Page, CP;Della Pasqua, OE
通讯作者：
Della Pasqua, OE
影响因子：
10
作者：
Pinto-Plata, VM;Müllerova, H;Celli, BR
通讯作者：
Celli, BR
DOI：
10.1164/ajrccm.154.4.8887607
发表时间：
1996-10-01
影响因子：
24.7
作者：
Rahman, I;Morrison, D;MacNee, W
通讯作者：
MacNee, W