Hypocholesterolemic effect of katsuobushi, smoke-dried bonito, prevents ovarian hormone deficiency-induced hypercholesterolemia.
Hypocholesterolemic effect of katsuobushi, smoke-dried bonito, prevents ovarian hormone deficiency-induced hypercholesterolemia.
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烟干鲣鱼的降胆固醇作用可预防卵巢激素缺乏引起的高胆固醇血症。
DOI：
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发表时间：
2007
影响因子：
1.6
通讯作者：
K. Ebihara
中科院分区：
文献类型：
--
作者：
J. Matsumoto;Kazuo Enami;M. Doi;T. Kishida;K. Ebihara
本研究的目的是检查是否katsuobushi，烟熏干鲣鱼（KB），这是一种传统的日本食品，防止卵巢激素缺乏引起的高胆固醇血症。在实验1中，卵巢切除大鼠（OVX-大鼠）喂养含有酪蛋白或KB的纯化饮食。与酪蛋白日粮相比，KB日粮降低了血浆胆固醇浓度和蛋白质表观消化率，增加了粪干重和粪胆汁酸排泄量。在实验2中，去卵巢大鼠喂养以下四种饮食之一：含有玉米油或鱼油的酪蛋白饮食（CA/CO或CA/FO），或含有经微生物蛋白酶处理后的KB的消化或未消化部分的饮食（KBE或KBR）。KBR主要含有两种组分：油和KB来源的蛋白酶未消化蛋白。与CA/CO日粮相比，KBE日粮不影响血浆和肝脏脂质浓度、表观蛋白质消化率和粪便胆汁酸排泄。然而，KBR和CA/FO饮食降低了血浆胆固醇和三酰甘油（TAG）浓度和肝脏总脂质和TAG浓度，但增加了肝脏总胆固醇和酯化胆固醇浓度。KBR饮食增加粪便胆汁酸排泄和粪便干重，而CA/FO饮食没有。因此，KB对卵巢激素缺乏相关的血浆胆固醇浓度增加的预防作用似乎是通过胆汁酸与耐药蛋白结合促进胆汁酸分泌而增加胆汁酸排泄介导的。
The purpose of this study was to examine whether katsuobushi, smoked-dried bonito (KB), which is a traditional Japanese food, prevents ovarian hormone deficiency-induced hypercholesterolemia. In experiment 1, ovariectomized rats (OVX-rats) were fed a purified diet containing casein or KB. Compared with the casein diet, the KB diet reduced the plasma cholesterol concentration and apparent protein digestibility, and increased the fecal dry weight and fecal bile acid excretion. In experiment 2, OVX-rats were fed one of the following four diets: casein diet containing corn oil or fish oil (CA/CO or CA/FO), or a diet containing the digested or undigested fraction of KB after treatment with microbial protease (KBE or KBR). KBR contains mainly two components: oil and protease-undigested protein of KB origin. In comparison with the CA/CO diet, the KBE diet did not affect the plasma and liver lipids concentrations, apparent protein digestibility nor fecal bile acid excretion. However, the KBR and CA/FO diets reduced the plasma cholesterol and triacylglycerol (TAG) concentrations and the liver total lipid and TAG concentrations, but increased the liver total and esterified cholesterol concentrations. The KBR diet increased fecal bile acid excretion and fecal dry weight, whereas the CA/FO diet did not. Thus, the preventive effect of KB on the ovarian hormone deficiency-associated increase in plasma cholesterol concentration appears to be mediated by an increase in bile acid excretion through a promoted secretion of bile acids by the binding of bile acids to resistant proteins.
膳食鱼油刺激大鼠肝脏低密度脂蛋白转运。
DOI：
10.1172/jci114195
发表时间：
1989
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Ventura,MA;Woollett,LA;Spady,DK
通讯作者：
Spady,DK
影响因子：
158.5
作者：
Grodstein, F;Stampfer, MJ;Hennekens, CH
通讯作者：
Hennekens, CH
DOI：
10.1093/jn/125.suppl_3.589s
发表时间：
1995-03
期刊：
The Journal of nutrition
影响因子：
--
作者：
D. Kritchevsky
通讯作者：
D. Kritchevsky