Sex Hormones Regulate Innate Immune Cells and Promote Sex Differences in Respiratory Virus Infection.
Sex Hormones Regulate Innate Immune Cells and Promote Sex Differences in Respiratory Virus Infection.
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DOI：
10.3389/fimmu.2018.01653
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发表时间：
2018
影响因子：
7.3
通讯作者：
Kovats S
中科院分区：
文献类型：
--
作者：
Kadel S;Kovats S
在人类和小鼠模型中广泛记录了呼吸道病毒感染发病率和严重程度的性别差异，并与稳态和肺部感染中先天免疫细胞数量和/或功能反应的性别偏倚相关。同样，青春期、妊娠和绝经/衰老时性激素水平的变化与先天免疫的定性和定量差异有关。免疫细胞表达雌激素（ERα和ERβ）、雄激素（AR）和孕酮（PR）的受体，对性激素水平或受体的实验操作表明，性激素受体活性通常是呼吸道免疫细胞数量和/或功能反应的性别差异的基础。虽然优雅的研究已经定义了先天免疫细胞中性激素和受体的机制作用，但关于骨髓细胞和先天淋巴细胞中ER、PR和AR促进肺中抗病毒免疫的启动和消退的细胞和分子作用机制仍有待了解。在这里，我们回顾了性别差异和性激素调节先天免疫细胞在肺内稳态和呼吸道病毒感染的文献。
Sex differences in the incidence and severity of respiratory virus infection are widely documented in humans and murine models and correlate with sex biases in numbers and/or functional responses of innate immune cells in homeostasis and lung infection. Similarly, changes in sex hormone levels upon puberty, pregnancy, and menopause/aging are associated with qualitative and quantitative differences in innate immunity. Immune cells express receptors for estrogens (ERα and ERβ), androgens (AR), and progesterone (PR), and experimental manipulation of sex hormone levels or receptors has revealed that sex hormone receptor activity often underlies sex differences in immune cell numbers and/or functional responses in the respiratory tract. While elegant studies have defined mechanistic roles for sex hormones and receptors in innate immune cells, much remains to be learned about the cellular and molecular mechanisms of action of ER, PR, and AR in myeloid cells and innate lymphocytes to promote the initiation and resolution of antiviral immunity in the lung. Here, we review the literature on sex differences and sex hormone regulation in innate immune cells in the lung in homeostasis and upon respiratory virus infection.
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影响因子：
8
作者：
Califano D;Furuya Y;Roberts S;Avram D;McKenzie ANJ;Metzger DW
通讯作者：
Metzger DW
DOI：
10.1016/b978-0-12-802388-4.00004-5
发表时间：
2016-01-01
期刊：
SEX DIFFERENCES IN PHYSIOLOGY
影响因子：
--
作者：
Buskiewicz, Iwona A.;Huber, Sally A.;Fairweather, DeLisa
通讯作者：
Fairweather, DeLisa
影响因子：
15.9
作者：
Ashcroft, GS;Mills, SJ
通讯作者：
Mills, SJ
DOI：
10.1111/j.1600-0897.1995.tb00965.x
发表时间：
1995-12-01
影响因子：
3.6
作者：
BENHUR, H;MOR, G;KOHEN, F
通讯作者：
KOHEN, F
影响因子：
20.3
作者：
Bengtsson, ÅK;Ryan, EJ;Clark, EA
通讯作者：
Clark, EA