Salmonellae PhoPQ regulation of the outer membrane to resist innate immunity.
Salmonellae PhoPQ regulation of the outer membrane to resist innate immunity.
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DOI：
10.1016/j.mib.2013.12.005
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发表时间：
2014-02
影响因子：
5.4
通讯作者：
Miller, Samuel I.
中科院分区：
文献类型：
--
作者：
Dalebroux, Zachary D.;Miller, Samuel I.
鲑鱼感觉宿主的线索，以调节细菌的生存和复制在宿主组织内的重要属性。PhoPQ双组分调节系统感知吞噬体酸化和阳离子抗菌肽，以调节细菌包膜的蛋白质和脂质含量。PhoPQ调节的外膜脂质成分包括脂多糖和甘油磷脂。受PhoPQ调控的包膜蛋白包括：毒力相关分泌系统的组分、鞭毛装置、膜转运系统和可能是外膜结构组分的蛋白质。细菌表面的PhoPQ改变导致细菌对阳离子抗菌肽（CAMP）的抗性增加，先天免疫系统的检测减少。这篇综述强调了外膜作为环境调节细胞器的复杂性。
Salmonellae sense host cues to regulate properties important for bacterial survival and replication within host tissues. The PhoPQ two-component regulatory system senses phagosome acidification and cationic antimicrobial peptides to regulate the protein and lipid contents of the bacterial envelope. PhoPQ regulated lipid components of the outer membrane include lipopolysaccharide and glycerolphospholipids. Envelope proteins regulated by PhoPQ, include: components of virulence associated secretion systems, the flagellar apparatus, membrane transport systems, and proteins that are likely structural components of the outer membrane. PhoPQ alteration of the bacterial surface results in increased bacterial resistance to cationic antimicrobial peptides (CAMP) and decreased detection by the innate immune system. This review highlights the complexity of the outer membrane as an environmentally regulated organelle.
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