Vascular oxidative stress: the common link in hypertensive and diabetic vascular disease.
Vascular oxidative stress: the common link in hypertensive and diabetic vascular disease.
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DOI：
10.1097/fjc.0b013e3181d89670
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发表时间：
2010-04
影响因子：
3
通讯作者：
Tong X
中科院分区：
文献类型：
--
作者：
Cohen RA;Tong X
高血压和糖尿病中的血管疾病与氧化剂增加有关。氧化剂来自NADPH氧化酶、黄嘌呤氧化酶和线粒体。超氧阴离子和过氧化氢由白细胞和血管细胞产生。诱导型一氧化氮合酶产生过量的一氧化氮，而强氧化剂过氧亚硝酸盐由超氧化物和一氧化氮形成。氧化剂对蛋白质的损伤是选择性的，影响特定的氧化剂敏感的氨基酸残基。对于一些重要的血管蛋白，例如内皮型一氧化氮合酶、前列环素合酶和超氧化物歧化酶，单个敏感氨基酸的氧化使酶失活。抗氧化剂的有益效果，至少在高血压和糖尿病的动物模型中，可以部分归因于对这些和其他蛋白质的保护。缺乏其反应成分的突变蛋白可以概括一些疾病表型，表明氧化的致病作用。因此，高血压和糖尿病血管的许多共同的功能异常可能是由氧化剂引起的。尽管使用抗氧化剂的研究在患者中失败，但使用HMG CoA还原酶抑制剂、血栓烷A2拮抗剂和多酚成功治疗血管疾病可能取决于它们的抗炎作用和减少破坏性氧化剂产生的能力。
Vascular disease in hypertension and diabetes is associated with increased oxidants. The oxidants arise from NADPH oxidase, xanthine oxidase, and mitochondria. Superoxide anion and hydrogen peroxide are produced by both leukocytes and vascular cells. Nitric oxide is produced in excess by inducible nitric oxide synthase, and the potent oxidant, peroxynitrite, is formed from superoxide and nitric oxide. The damage to proteins caused by oxidants is selective, affecting specific oxidant-sensitive amino acid residues. With some important vascular proteins, for example endothelial nitric oxide synthase, prostacyclin synthase, and superoxide dismutase, oxidation of a single susceptible amino acid inactivates the enzyme. The beneficial effects of antioxidants, at least in animal models of hypertension and diabetes, can in part be ascribed to protection of these and other proteins. Mutant proteins lacking their reactive constituent can recapitulate some disease phenotypes suggesting a pathogenic role of the oxidation. Thus, many of the shared functional abnormalites of hypertensive and diabetic blood vessels may be caused by oxidants. Although studies using antioxidants have failed in patients, the successful treatment of vascular disease with HMG CoA reductase inhibitors, thromboxane A2 antagonists, and polyphenols may depend upon their anti-inflammatory effects and ability to decrease production of damaging oxidants.
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影响因子：
8.3
作者：
Beswick, RA;Zhang, HF;Webb, RC
通讯作者：
Webb, RC
影响因子：
4.8
作者：
Ambasta, RK;Kumar, P;Brandes, RP
通讯作者：
Brandes, RP
影响因子：
4.8
作者：
Clavreul, N;Adachi, T;Cohen, RA
通讯作者：
Cohen, RA
影响因子：
105.7
作者：
Adler, AI;Stratton, IM;Holman, RR
通讯作者：
Holman, RR
DOI：
10.3109/10715769009149883
发表时间：
1990-01-01
期刊：
FREE RADICAL RESEARCH COMMUNICATIONS
影响因子：
--
作者：
ARUOMA, OI;EVANS, PJ;HALLIWELL, B
通讯作者：
HALLIWELL, B