Semaphorins and Plexins in Kidney Disease
Semaphorins and Plexins in Kidney Disease
复制标题
肾脏疾病中的信号蛋白和丛蛋白
作者：
Jingjing Xia;T. Worzfeld
脑信号蛋白是一种可溶性或膜结合的信号蛋白，控制着细胞间通讯、分化、形态和功能的多个方面。它们的大部分作用是由一个称为丛蛋白的跨膜受体家族介导的。脑信号蛋白和丛蛋白已成为各种器官中多种生理和病理生理过程的中枢调节因子。本文综述了脑信号蛋白和丛蛋白在肾脏病理生理中的作用及其作为肾脏疾病生物标志物的潜在用途。
Semaphorins are soluble or membrane-bound cues, which control multiple aspects of cell-cell communication, differentiation, morphology and function. Most of their effects are mediated by a family of transmembrane receptors called plexins. Semaphorins and plexins have emerged as central regulators of diverse physiological and pathophysiological processes in various organs. This review summarizes the role of semaphorins and plexins in renal pathophysiology and their potential use as biomarkers of kidney disease.
影响因子：
15.9
作者：
Bonventre, Joseph V.;Yang, Li
通讯作者：
Yang, Li
影响因子：
6.1
作者：
Doi, Kent;Noiri, Eisei;Ramesh, Ganesan
通讯作者：
Ramesh, Ganesan
DOI：
10.1152/ajprenal.00177.2014
发表时间：
2014-07-15
影响因子：
4.2
作者：
Ranganathan, Punithavathi;Jayakumar, Calpurnia;Ramesh, Ganesan
通讯作者：
Ramesh, Ganesan