Potential of Stem Cell-Based Therapy for Ischemic Stroke.
Potential of Stem Cell-Based Therapy for Ischemic Stroke.
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DOI：
10.3389/fneur.2018.00034
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发表时间：
2018
影响因子：
3.4
通讯作者：
Shuaib A
中科院分区：
文献类型：
--
作者：
Marei HE;Hasan A;Rizzi R;Althani A;Afifi N;Cenciarelli C;Caceci T;Shuaib A
缺血性中风是世界范围内的主要健康问题之一。唯一FDA批准的用于急性缺血性卒中的抗血栓药物是组织纤溶酶原激活剂。几项研究致力于评估不同类型的干细胞如神经干细胞（NSC）、间充质干细胞、胚胎干细胞和人诱导多能干细胞衍生的NSC作为缺血性中风的治疗的治疗潜力。这些研究的结果是有趣的，但其中许多人提出了相互矛盾的结果。此外，移植的干/祖细胞发挥其作用的机制在很大程度上是未知的。在这篇综述中，我们将提供与使用基于干细胞的中风治疗相关的不同临床前和临床研究的概要，并探讨与使用不同类型的干细胞相关的可能的有益/有害结果。由于在大多数记录的关于使用干细胞作为中风的潜在治疗干预的临床试验中实施的时间窗有限/短，因此仍然需要在细胞植入后的较长时间窗内评估干预的功效的进一步临床试验。
Ischemic stroke is one of the major health problems worldwide. The only FDA approved anti-thrombotic drug for acute ischemic stroke is the tissue plasminogen activator. Several studies have been devoted to assessing the therapeutic potential of different types of stem cells such as neural stem cells (NSCs), mesenchymal stem cells, embryonic stem cells, and human induced pluripotent stem cell-derived NSCs as treatments for ischemic stroke. The results of these studies are intriguing but many of them have presented conflicting results. Additionally, the mechanism(s) by which engrafted stem/progenitor cells exert their actions are to a large extent unknown. In this review, we will provide a synopsis of different preclinical and clinical studies related to the use of stem cell-based stroke therapy, and explore possible beneficial/detrimental outcomes associated with the use of different types of stem cells. Due to limited/short time window implemented in most of the recorded clinical trials about the use of stem cells as potential therapeutic intervention for stroke, further clinical trials evaluating the efficacy of the intervention in a longer time window after cellular engraftments are still needed.
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影响因子：
4.3
作者：
Chen L;Zhang G;Khan AA;Guo X;Gu Y
通讯作者：
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作者：
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通讯作者：
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