Dual role of microRNAs in NAFLD.
Dual role of microRNAs in NAFLD.
复制标题
DOI：
10.3390/ijms14048437
复制
发表时间：
2013-04-17
影响因子：
5.6
通讯作者：
Nobili V
中科院分区：
文献类型：
--
作者：
Ceccarelli S;Panera N;Gnani D;Nobili V
microRNA是重要的转录后调节因子，参与多种病理生理过程。它们通常影响mRNA的稳定性或翻译，最终导致靶基因表达的抑制。值得注意的是，人们认为microRNA对于调节代谢相关疾病（如非酒精性脂肪性肝病（NAFLD））期间的基因表达至关重要。几项研究确定了与NAFLD不同组织学特征相关的特定microRNA表达谱，包括动物模型和患者。因此，某些microRNA的特异性表达可能具有巨大的诊断潜力。此外，microRNA也已成为治疗NAFLD相关肝损伤的可能治疗靶点。在这篇综述中，我们讨论了microRNA作为潜在的非侵入性早期诊断标志物和作为NAFLD及其更严重的肝脏并发症的新的治疗靶点的实验证据。
MicroRNAs are important post-transcriptional regulators in different pathophysiological processes. They typically affect the mRNA stability or translation finally leading to the repression of target gene expression. Notably, it is thought that microRNAs are crucial for regulating gene expression during metabolic-related disorders, such as nonalcoholic fatty liver disease (NAFLD). Several studies identify specific microRNA expression profiles associated to different histological features of NAFLD, both in animal models and in patients. Therefore, specific assortments of certain microRNAs could have enormous diagnostic potentiality. In addition, microRNAs have also emerged as possible therapeutic targets for the treatment of NAFLD-related liver damage. In this review, we discuss the experimental evidence about microRNAs both as potential non-invasive early diagnostic markers and as novel therapeutic targets in NAFLD and its more severe liver complications.
登录
查看更多内容
影响因子：
4.5
作者：
Cai, XZ;Hagedorn, CH;Cullen, BR
通讯作者：
Cullen, BR
影响因子：
64.8
作者：
Chendrimada, TP;Gregory, RI;Shiekhattar, R
通讯作者：
Shiekhattar, R
影响因子：
4.8
作者：
Gerin, Isabelle;Clerbaux, Laure-Alix;Bommer, Guido T.
通讯作者：
Bommer, Guido T.
人类脂肪肝病：旧问题和新见解。
DOI：
10.1126/science.1204265
发表时间：
2011-06-24
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Cohen JC;Horton JD;Hobbs HH
通讯作者：
Hobbs HH
影响因子：
64.8
作者：
Davis, Brandi N.;Hilyard, Aaron C.;Hata, Akiko
通讯作者：
Hata, Akiko