Hemiosteoporosis after severe stroke, independent of changes in body composition and weight.
Hemiosteoporosis after severe stroke, independent of changes in body composition and weight.
复制标题
严重中风后发生半身骨质疏松症，与身体成分和体重的变化无关。
作者：
A. Ramnemark;Lars Nyberg;Ronny Lorentzon;Tommy Olsson;Yngve Gustafson
背景和目的
骨折是卒中后的严重并发症，卒中患者发生髋部骨折的风险比参考人群高2 - 4倍。中风后的骨折可能是由于偏侧骨质疏松症的发展和意外福尔斯的高发生率引起的。本研究的目的是调查严重中风后第一年内偏侧骨质疏松症的发展与身体成分的其他变化的关系。
方法
该研究包括24名中风后广泛性轻瘫患者。在中风发作后1、4、7和12个月，通过双能X线骨密度仪评估骨矿物质含量（BMC）和脂肪及瘦体重。
结果
在中风后的第一年，全身BMC的损失是显著的（-1.6%; P<0.05），但总瘦体重或脂肪质量没有显著变化。入选时，患侧的瘦体重、脂肪质量和BMC无显著性差异，但随访时患侧BMC较入选时同侧显著下降（-7.5%，P <0.01）。脂肪量的侧差异在腿部（9.3%; P<0.001）和全侧（4.3%; P<0.001）之间变得显著。8%; P<0.01）。瘦体重只有轻微的变化。BMC的损失与体重变化无关。
结论
在严重中风后的第一年，患者出现明显的偏侧骨质疏松症。这与瘦肉或脂肪质量的一般变化无关。偏侧骨质疏松症的发生与卒中后体重变化无关。
BACKGROUND AND PURPOSE
Fractures are a serious complication after stroke, and the risk of hip fractures among stroke patients is increased 2 to 4 times versus a reference population. Fractures after stroke are probably caused by the development of hemiosteoporosis and the high incidence of accidental falls. The aim of this study was to investigate the development of hemiosteoporosis in relation to other changes in body composition during the first year after severe stroke.
METHODS
The study included 24 patients with extensive paresis after stroke. Bone mineral content (BMC) and fat and lean mass were assessed 1, 4, 7, and 12 months after stroke onset by a dual-energy x-ray absorptiometer.
RESULTS
The loss of total body BMC was significant during the first year after stroke (-1.6%; P<0.05), but there were no significant changes in total lean or fat mass. At inclusion, there were no significant differences between sides in lean or fat mass or BMC, but during follow-up, BMC of the affected side decreased significantly compared with the same side at inclusion (-7.5%; P<0.01). Side differences in fat mass became significant between legs (9.3%; P<0.001) and whole sides (4. 8%; P<0.01). There were only minor side changes in lean mass. Loss of BMC was independent of weight changes.
CONCLUSIONS
During the first year after severe stroke, patients developed pronounced hemiosteoporosis. This was not associated with general changes in lean or fat mass. The development of hemiosteoporosis was independent of weight changes after stroke.
影响因子：
7.1
作者：
Baumgartner, RN;Stauber, PM;Garry, PJ
通讯作者：
Garry, PJ