Fe-S proteins that regulate gene expression.

Fe-S proteins that regulate gene expression.
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DOI:
10.1016/j.bbamcr.2014.11.018
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发表时间:
2015-06
影响因子:
5.1
通讯作者:
Kiley, Patricia J.
Kiley, Patricia J.
中科院分区:
生物学2区
文献类型:
--
作者:
Mettert, Erin L.;Kiley, Patricia J.

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铁-硫(Fe-S)簇蛋白是一种存在于大多数生物体内的基因表达调控蛋白。它们的Fe-S辅因子的先天化学性质使得这些调节蛋白非常适合用于感测环境信号,例如气体(例如O2和NO)、Fe和Fe-S簇的水平、活性氧物质和氧化还原循环化合物,以随后介导适应性反应。在这里,我们回顾了最近的研究结果,这些非常重要的Fe-S调节蛋白的机制和功能提供了宝贵的见解。
Iron-sulfur (Fe-S) cluster containing proteins that regulate gene expression are present in most organisms. The innate chemistry of their Fe-S cofactors makes these regulatory proteins ideal for sensing environmental signals, such as gases (e.g. O2 and NO), levels of Fe and Fe-S clusters, reactive oxygen species, and redox cycling compounds, to subsequently mediate an adaptive response. Here we review the recent findings that have provided invaluable insight into the mechanism and function of these highly significant Fe-S regulatory proteins.
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