Enhancing Protective Efficacy of Poultry Vaccines through Targeted Delivery of Antigens to Antigen-Presenting Cells.
Enhancing Protective Efficacy of Poultry Vaccines through Targeted Delivery of Antigens to Antigen-Presenting Cells.
复制标题
DOI：
10.3390/vaccines6040075
复制
发表时间：
2018-11-15
期刊：
影响因子：
7.8
通讯作者：
Iqbal M
中科院分区：
文献类型：
--
作者：
Shrestha A;Sadeyen JR;Iqbal M
包括禽流感、马立克氏病和新城疫在内的禽病毒性疾病对世界各地依赖家禽贸易的经济造成损害。禽流感病毒也构成重大人畜共患威胁。疫苗接种是控制这些家禽疾病的重要且广泛使用的方法。然而，目前的疫苗不能提供充分的保护或无菌免疫。因此，需要开发改进的疫苗。开发改进疫苗的主要目的是在接种疫苗的动物中诱导强烈且特异性的体液和细胞免疫。用于增强疫苗免疫原性的一种策略是将保护性抗原选择性递送至抗原呈递细胞 (APC)，包括树突状细胞、巨噬细胞和 B 细胞。 APC 通过其捕获、处理抗原并将其呈递给 T 细胞和 B 细胞的能力，在免疫反应的启动和维持中发挥着核心作用。选择性靶向 APC 的疫苗技术是通过将抗原与 APC 靶向的单克隆抗体或配体偶联来实现的。本综述的目的是讨论选择性地将抗原递送至 APC 的现有策略，以在家禽中有效开发疫苗。
Avian viral diseases including avian influenza, Marek’s disease and Newcastle disease are detrimental to economies around the world that depend on the poultry trade. A significant zoonotic threat is also posed by avian influenza viruses. Vaccination is an important and widely used method for controlling these poultry diseases. However, the current vaccines do not provide full protection or sterile immunity. Hence, there is a need to develop improved vaccines. The major aim of developing improved vaccines is to induce strong and specific humoral and cellular immunity in vaccinated animals. One strategy used to enhance the immunogenicity of vaccines is the selective delivery of protective antigens to antigen-presenting cells (APCs) including dendritic cells, macrophages and B cells. APCs have a central role in the initiation and maintenance of immune responses through their ability to capture, process and present antigens to T and B cells. Vaccine technology that selectively targets APCs has been achieved by coupling antigens to monoclonal antibodies or ligands that are targeted by APCs. The aim of this review is to discuss existing strategies of selective delivery of antigens to APCs for effective vaccine development in poultry.
登录
查看更多内容
影响因子：
15.3
作者：
Bonifaz, L;Bonnyay, D;Mahnke, K;Rivera, M;Nussenzweig, MC;Steinman, RM
通讯作者：
Steinman, RM
影响因子：
3.7
作者：
Boeglin E;Smulski CR;Brun S;Milosevic S;Schneider P;Fournel S
通讯作者：
Fournel S
影响因子：
3.1
作者：
Beal, RK;Powers, C;Smith, AL
通讯作者：
Smith, AL
影响因子：
4.1
作者：
Basto AP;Leitão A
通讯作者：
Leitão A
DOI：
10.3390/ph5111177
发表时间：
2012-11-01
期刊：
Pharmaceuticals (Basel, Switzerland)
影响因子：
--
作者：
Erazo-Oliveras A;Muthukrishnan N;Baker R;Wang TY;Pellois JP
通讯作者：
Pellois JP