Macrophage as a Peripheral Pain Regulator.
Macrophage as a Peripheral Pain Regulator.
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DOI：
10.3390/cells10081881
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发表时间：
2021-07-24
期刊：
影响因子：
6
通讯作者：
Kawabata A
中科院分区：
文献类型：
--
作者：
Domoto R;Sekiguchi F;Tsubota M;Kawabata A
神经免疫串扰涉及躯体和内脏病理性疼痛，包括炎症和神经病理性成分。除了脊髓和脊髓上疼痛处理所必需的小胶质细胞外，骨髓源性浸润巨噬细胞和/或组织驻留巨噬细胞与初级传入神经元的相互作用调节外周组织中的疼痛信号。最近的研究发现了组织驻留巨噬细胞的先前未知的特征，例如它们的起源和与疼痛信号调节的关联。外周神经巨噬细胞和肠道驻留巨噬细胞，除了成体单核细胞来源的浸润性巨噬细胞外，还分泌多种介质，如肿瘤坏死因子-α、白细胞介素（IL）-1β、IL-6、高迁移率族蛋白1和骨形态发生蛋白2（BMP 2），调节初级传入神经的兴奋性。神经源性介质包括神经肽、ATP和巨噬细胞集落刺激因子，调节各种巨噬细胞的活性或极化。因此，巨噬细胞在稳态条件下具有多任务，并通过与神经元相互作用参与躯体和内脏病理性疼痛。
A neuroimmune crosstalk is involved in somatic and visceral pathological pain including inflammatory and neuropathic components. Apart from microglia essential for spinal and supraspinal pain processing, the interaction of bone marrow-derived infiltrating macrophages and/or tissue-resident macrophages with the primary afferent neurons regulates pain signals in the peripheral tissue. Recent studies have uncovered previously unknown characteristics of tissue-resident macrophages, such as their origins and association with regulation of pain signals. Peripheral nerve macrophages and intestinal resident macrophages, in addition to adult monocyte-derived infiltrating macrophages, secrete a variety of mediators, such as tumor necrosis factor-α, interleukin (IL)-1β, IL-6, high mobility group box 1 and bone morphogenic protein 2 (BMP2), that regulate the excitability of the primary afferents. Neuron-derived mediators including neuropeptides, ATP and macrophage-colony stimulating factor regulate the activity or polarization of diverse macrophages. Thus, macrophages have multitasks in homeostatic conditions and participate in somatic and visceral pathological pain by interacting with neurons.
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DOI：
10.1523/jneurosci.3795-08.2008
发表时间：
2008-12-24
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Binshtok AM;Wang H;Zimmermann K;Amaya F;Vardeh D;Shi L;Brenner GJ;Ji RR;Bean BP;Woolf CJ;Samad TA
通讯作者：
Samad TA
影响因子：
5.4
作者：
Baliu-Pique, Mariona;Jusek, Gabriela;Holzmann, Bernhard
通讯作者：
Holzmann, Bernhard
影响因子：
15.9
作者：
Dai, Yi;Wang, Shenglan;Noguchi, Koichi
通讯作者：
Noguchi, Koichi
影响因子：
5
作者：
Badiei, Alireza;Rivers-Auty, Jack;Bhatia, Madhav
通讯作者：
Bhatia, Madhav
影响因子：
13.9
作者：
Costigan M;Scholz J;Woolf CJ
通讯作者：
Woolf CJ