Demographic and Operational Factors Predicting Study Completion in a Multisite Case-Control Study of Preschool Children.
Demographic and Operational Factors Predicting Study Completion in a Multisite Case-Control Study of Preschool Children.
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DOI：
10.1093/aje/kwx262
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发表时间：
2018-03-01
影响因子：
5
通讯作者：
Daniels JL
中科院分区：
文献类型：
--
作者：
Bradley CB;Browne EN;Alexander AA;Collins J;Dahm JL;DiGuiseppi CG;Levy SE;Moody EJ;Schieve LA;Windham GC;Young L;Daniels JL
参与者的流失会限制从研究结果中得出的推论并增加研究成本。我们研究了与完成探索早期发展研究（2007-2011）相关的因素，这是一项针对学龄前儿童自闭症谱系障碍危险因素的多成分病例对照研究，在加利福尼亚州、科罗拉多州、佐治亚州、马里兰州、北卡罗来纳州和宾夕法尼亚州进行。参与者 (n = 3,769) 被要求完成电话采访、问卷调查、现场评估和生物采样。我们使用混合效应逻辑回归模型检查了参与者的人口统计和管理因素是否可以预测完成情况。个别关键研究部分的完成率通常为 70% 或更高。然而，58% 的家庭完成了所有符合方案的数据元素（先验定义为关键研究组成部分）。每个方案的完成情况根据母亲的年龄、种族、教育水平、到诊所的驾驶距离、尝试联系的次数以及提供的电话号码的数量而有所不同（所有 P < 0.05）。尽管为病例确认收集了额外的数据，但病例状态与完成无关。对完成早期访谈的子集的分析显示，收入、主要语言、成人人数或患有慢性病的儿童人数等家庭因素在完成情况上没有差异。种族和教育程度的完成差异非常显着，在制定未来的招募和完成策略时需要仔细考虑。
Participant attrition can limit inferences drawn from study results and inflate research costs. We examined factors associated with completion of the Study to Explore Early Development (2007–2011), a multiple-component, case-control study of risk factors for autism spectrum disorder in preschoolers, conducted in California, Colorado, Georgia, Maryland, North Carolina, and Pennsylvania. Participants (n = 3,769) were asked to complete phone interviews, questionnaires, an in-person evaluation, and biologic sampling. We examined whether participant demographic and administrative factors predicted completion using mixed-effects logistic regression models. Completion of individual key study components was generally 70% or higher. However, 58% of families completed all per-protocol data elements (defined a priori as key study components). Per-protocol completion differed according to mother’s age, race, educational level, driving distance to clinic, number of contact attempts to enroll, and number of telephone numbers provided (all P < 0.05). Case status was not associated with completion, despite additional data collection for case-confirmation. Analysis of a subset that completed an early interview revealed no differences in completion by household factors of income, primary language spoken, number of adults, or number of children with chronic conditions. Differences in completion by race and education were notable and need to be carefully considered in developing future recruitment and completion strategies.
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影响因子：
2.1
作者：
Koss, E;Peterson, B;Fillenbaum, GG
通讯作者：
Fillenbaum, GG
影响因子：
2.7
作者：
Siddiqi, Azfar-e-Alam;Sikorskii, Alla;Given, Barbara
通讯作者：
Given, Barbara
影响因子：
7.2
作者：
Hewitt, Catherine E.;Kumaravel, Bharathy;Torgerson, David J.
通讯作者：
Torgerson, David J.
影响因子：
1.9
作者：
Fischer, EH;Dornelas, EA;Goethe, JW
通讯作者：
Goethe, JW
影响因子：
7.2
作者：
Goldberg, Marcel;Chastang, Jean Francois;Leclerc, Annette
通讯作者：
Leclerc, Annette