Mitochondrial β-oxidation of adipose-derived fatty acids by osteoblasts fuels parathyroid hormone-induced bone formation.
Mitochondrial β-oxidation of adipose-derived fatty acids by osteoblasts fuels parathyroid hormone-induced bone formation.
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DOI：
10.1172/jci.insight.165604
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发表时间：
2023-03-22
期刊：
影响因子：
8
通讯作者：
Riddle, Ryan C. .
中科院分区：
文献类型：
--
作者：
Alekos, Nathalie S. .;Kushwaha, Priyanka;Kim, Soohyun P. .;Li, Zhu;Abood, Abdullah;Dirckx, Naomi;Aja, Susan;Kodama, Joe;Garcia-Diaz, Jean G. .;Otsuru, Satoru;Rendina-Ruedy, Elizabeth;Wolfgang, Michael J. .;Riddle, Ryan C. .
骨形成的能量消耗需要成骨细胞与诸如脂肪等能够提供能量密集型常量营养素的组织协调其活动。在间歇性甲状旁腺激素（PTH）治疗（一种用于降低骨折风险的策略）的情况下，骨形成之前会发生全身性脂质内稳态的改变。为了研究在PTH诱导的骨形成过程中成骨细胞进行脂肪酸氧化的需求，我们对成骨细胞特异性线粒体长链β - 氧化缺陷的小鼠以及脂肪细胞特异性PTH受体或脂肪甘油三酯脂肪酶缺陷的小鼠进行了合成代谢治疗方案。PTH增加了脂肪细胞释放脂肪酸以及成骨细胞的β - 氧化，而基因小鼠模型对该激素的合成代谢作用具有抗性。总体而言，这些数据表明PTH的合成代谢作用需要骨骼和脂肪之间的协同信号传导，其中脂解反应释放出脂肪酸，这些脂肪酸被成骨细胞氧化以为骨形成提供能量。
The energetic costs of bone formation require osteoblasts to coordinate their activities with tissues, like adipose, that can supply energy-dense macronutrients. In the case of intermittent parathyroid hormone (PTH) treatment, a strategy used to reduce fracture risk, bone formation is preceded by a change in systemic lipid homeostasis. To investigate the requirement for fatty acid oxidation by osteoblasts during PTH-induced bone formation, we subjected mice with osteoblast-specific deficiency of mitochondrial long-chain β-oxidation as well as mice with adipocyte-specific deficiency for the PTH receptor or adipose triglyceride lipase to an anabolic treatment regimen. PTH increased the release of fatty acids from adipocytes and β-oxidation by osteoblasts, while the genetic mouse models were resistant to the hormone’s anabolic effect. Collectively, these data suggest that PTH’s anabolic actions require coordinated signaling between bone and adipose, wherein a lipolytic response liberates fatty acids that are oxidized by osteoblasts to fuel bone formation.
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影响因子：
29
作者：
Kajimura D;Lee HW;Riley KJ;Arteaga-Solis E;Ferron M;Zhou B;Clarke CJ;Hannun YA;DePinho RA;Guo XE;Mann JJ;Karsenty G
通讯作者：
Karsenty G
影响因子：
5.2
作者：
Aaron N;Costa S;Rosen CJ;Qiang L
通讯作者：
Qiang L
DOI：
10.1152/ajpendo.00530.2014
发表时间：
2015-05-15
影响因子：
5.1
作者：
Dube, John J.;Sitnick, Mitch T.;Kershaw, Erin E.
通讯作者：
Kershaw, Erin E.
影响因子：
4.8
作者：
Dobnig, H;Turner, RT
通讯作者：
Turner, RT
影响因子：
8
作者：
Kim, Soohyun P.;Li, Zhu;Riddle, Ryan C.
通讯作者：
Riddle, Ryan C.