Focal adhesion kinase and endothelial cell apoptosis.
Focal adhesion kinase and endothelial cell apoptosis.
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DOI：
10.1016/j.mvr.2011.05.003
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发表时间：
2012-01
影响因子：
3.1
通讯作者：
Rounds S
中科院分区：
文献类型：
--
作者：
Lu Q;Rounds S
Focal adhesion kinase is a key component of cell-substratum adhesions, known as focal adhesion complexes. Growing evidence indicates that FAK is important in maintenance of normal cell survival and that disruption of FAK signaling results in loss of substrate adhesion and anoikis (apoptosis) of anchorage-dependent cells, such as endothelial cells. Basal FAK activity in non-stimulated endothelial cells is important in maintaining cell adhesion to integrins via PI3 kinase/Akt signaling. FAK activity is dependent upon small GTPase signaling. FAK also appears to be important in cardiomyocyte hypertrophy and hypoxia/reoxygenation-induced cell death. This review summaries the signaling pathways of FAK in prevention of apoptosis and the role of FAK in mediating adenosine and homocysteine-induced endothelial cell apoptosis and in cardiovascular diseases.
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影响因子：
64.5
作者：
Du, CY;Fang, M;Wang, XD
通讯作者：
Wang, XD
DOI：
10.1083/jcb.107.3.1215
发表时间：
1988-09
期刊：
The Journal of cell biology
影响因子：
--
作者：
Dejana E;Colella S;Conforti G;Abbadini M;Gaboli M;Marchisio PC
通讯作者：
Marchisio PC
影响因子：
5.6
作者：
CHENG, YF;KRAMER, RH
通讯作者：
KRAMER, RH
影响因子：
3.3
作者：
DREYFUSS, D;SOLER, P;SAUMON, G
通讯作者：
SAUMON, G
DOI：
10.1152/ajplung.1997.273.2.l485
发表时间：
1997-08-01
影响因子：
4.9
作者：
Dawicki, DD;Chatterjee, D;Rounds, S
通讯作者：
Rounds, S