The Analgesic Effects of Static Magnetic Fields

The Analgesic Effects of Static Magnetic Fields
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静磁场的镇痛作用

DOI:
10.1002/bem.22323
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发表时间:
2021-01
影响因子:
1.9
通讯作者:
Xin Zhang
Xin Zhang
中科院分区:
生物学4区
文献类型:
--
作者:
Yixiang Fan;Xinmiao Ji;Lei Zhang;Xin Zhang

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疼痛是人们寻求医疗保健的最常见原因之一,这与大多数疾病状态有关。磁场(MFs)可以局部应用于人体的特定部位,具有高穿透性和时间控制性,这在民间治疗中有着长期争论的历史。本综述的目的是收集和分析静磁场镇痛作用的实验数据,以便我们对这一主题有一个科学的认识。我们收集了28项研究(25篇英文论文和3篇中文论文),并进行了适当的假对照,研究了smf对人类或小鼠疼痛缓解的影响。我们发现,文献中64%的人类研究和所有小鼠研究显示SMF具有积极的镇痛作用,这与SMF强度、治疗时间和疼痛类型等因素有关。更高的强度和/或更长的治疗时间,以及一些特定的疼痛类型,可能有更好的缓解疼痛的效果。初步的机制研究表明,膜受体,如辣椒素受体VR1/TRPV1,阿片受体和P2X3受体可能参与其中。通过描述实验证据和分析,我们发现,如果使用适当的SMF参数,SMF实际上对管理某些特定类型的疼痛具有相当大的希望。未来需要更多的研究综合评价SMF的参数及其对不同疼痛类型的镇痛作用,以及潜在的分子机制,以进一步验证其在疼痛管理中的治疗潜力。
Pain is one of the most common reasons why people seek medical care, which is related to most disease states. Magnetic fields (MFs) can be applied locally to specific parts of human bodies with high penetration and temporal control, which have a long-debated history in folk therapy. The purpose of this review is to collect and analyze experimental data about the analgesic effects of static magnetic fields (SMFs) so that we can have a scientific understanding regarding this topic. We collected 28 studies (25 English and 3 Chinese papers) with proper sham controls that investigated the effects of SMFs on pain relief in humans or mice. We found that 64% of the human studies and all mice studies in the literature showed positive analgesic effects of SMFs, which are related to factors including SMF intensity, treatment time, and pain types. Higher intensity and/or longer treatment time, as well as some specific pain types, may have better pain relief effects. Initial mechanistic studies indicated that membrane receptors, such as capsaicin receptor VR1/TRPV1, opioid receptors, and P2X3 receptors, might be involved. By describing experimental evidence and analysis, we found that SMFs actually hold considerable promise for managing some specific types of pain if proper SMF parameters are used. More studies comprehensively evaluating the parameters of SMF and its corresponding analgesic effects on different pain types, as well as the underlying molecular mechanisms, will be necessary to further validate its therapeutic potential in pain management in the future.
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