Differences in the strength of cortical and brainstem inputs to SSA and non-SSA neurons in the inferior colliculus.
Differences in the strength of cortical and brainstem inputs to SSA and non-SSA neurons in the inferior colliculus.
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DOI：
10.1038/srep10383
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发表时间：
2015-05-20
影响因子：
4.6
通讯作者：
Oliver DL
中科院分区：
文献类型：
--
作者：
Ayala YA;Udeh A;Dutta K;Bishop D;Malmierca MS;Oliver DL
在不断变化的听觉场景中，变化检测是听觉大脑执行的一项持续任务。中脑和听觉皮层中的神经元表现出刺激特异性适应（SSA）可能有助于这一过程。这些神经元适应频繁的声音，同时保持对罕见声音的兴奋性。在这里，我们测试是否显示SSA和那些没有的神经元是下丘（IC）中相同网络的一部分。我们记录了对频繁和罕见声音的反应，然后用逆行示踪剂标记这些神经元的位置，以将投射源与生理反应相关联。SSA神经元局限于非丘系亚部，并表现出广泛的感受野，而非SSA局限于中央核，并表现出狭窄的感受野。SSA神经元接收来自听觉皮层区域的强输入，而来自脑干核团的投射非常差甚至不存在。相反，缺乏SSA的神经元的主要输入来源是脑干核团。这些研究结果表明，听觉皮层输入偏向于IC突触域，这些突触域由SSA神经元填充，使它们能够将自上而下的信号与来自较低区域的传入感觉信息进行比较。
In an ever changing auditory scene, change detection is an ongoing task performed by the auditory brain. Neurons in the midbrain and auditory cortex that exhibit stimulus-specific adaptation (SSA) may contribute to this process. Those neurons adapt to frequent sounds while retaining their excitability to rare sounds. Here, we test whether neurons exhibiting SSA and those without are part of the same networks in the inferior colliculus (IC). We recorded the responses to frequent and rare sounds and then marked the sites of these neurons with a retrograde tracer to correlate the source of projections with the physiological response. SSA neurons were confined to the non-lemniscal subdivisions and exhibited broad receptive fields, while the non-SSA were confined to the central nucleus and displayed narrow receptive fields. SSA neurons receive strong inputs from auditory cortical areas and very poor or even absent projections from the brainstem nuclei. On the contrary, the major sources of inputs to the neurons that lacked SSA were from the brainstem nuclei. These findings demonstrate that auditory cortical inputs are biased in favor of IC synaptic domains that are populated by SSA neurons enabling them to compare top-down signals with incoming sensory information from lower areas.
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影响因子：
3.5
作者：
Ayala YA;Pérez-González D;Duque D;Nelken I;Malmierca MS
通讯作者：
Malmierca MS
影响因子：
3.5
作者：
Ayala YA;Malmierca MS
通讯作者：
Malmierca MS
影响因子：
1.9
作者：
Gutfreund, Yoram
通讯作者：
Gutfreund, Yoram
影响因子：
3.4
作者：
Anderson, L. A.;Malmierca, M. S.
通讯作者：
Malmierca, M. S.
DOI：
10.1098/rstb.2005.1622
发表时间：
2005-04-29
影响因子：
6.3
作者：
Friston, KJ
通讯作者：
Friston, KJ