Stimulus-specific adaptation and deviance detection in the inferior colliculus.
Stimulus-specific adaptation and deviance detection in the inferior colliculus.
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DOI：
10.3389/fncir.2012.00089
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发表时间：
2012
影响因子：
3.5
通讯作者：
Malmierca MS
中科院分区：
文献类型：
--
作者：
Ayala YA;Malmierca MS
对动物来说，在源源不断地向中枢神经系统输入感觉信息的过程中进行异常检测是至关重要的。这项任务需要神经元机制，允许通过去除统计冗余信号来有效地表示环境。近年来，人们通过对刺激特异性适应现象的研究，探讨了听觉偏差检测的神经元原理。SSA是神经元对常见或重复声音的反应性降低，而神经元对罕见声音保持高度敏感（Ulanovsky等人，）。这种现象可以在重复信号的背景下增强意外的、异常的刺激的显著性。SSA与被称为“失配负性”（MMN）的诱发电位有许多相似之处，它与听觉记忆和场景分析（Winkler等人，）等认知过程以及行为习惯（Netser等人，）有关。表现出SSA的神经元可以在听觉通路的几个层次上发现，从下丘（IC）到听觉皮层（AC）。在这篇综述中，我们介绍了IC中SSA研究的最新进展，旨在促进对听觉偏差检测的单神经元电生理的兴趣。神经元SSA对各种刺激特征的依赖性，如异常刺激的概率和重复率，以及AC和抑制在IC水平上形成SSA的作用。
Deviancy detection in the continuous flow of sensory information into the central nervous system is of vital importance for animals. The task requires neuronal mechanisms that allow for an efficient representation of the environment by removing statistically redundant signals. Recently, the neuronal principles of auditory deviance detection have been approached by studying the phenomenon of stimulus-specific adaptation (SSA). SSA is a reduction in the responsiveness of a neuron to a common or repetitive sound while the neuron remains highly sensitive to rare sounds (Ulanovsky et al.,). This phenomenon could enhance the saliency of unexpected, deviant stimuli against a background of repetitive signals. SSA shares many similarities with the evoked potential known as the “mismatch negativity,” (MMN) and it has been linked to cognitive process such as auditory memory and scene analysis (Winkler et al.,) as well as to behavioral habituation (Netser et al.,). Neurons exhibiting SSA can be found at several levels of the auditory pathway, from the inferior colliculus (IC) up to the auditory cortex (AC). In this review, we offer an account of the state-of-the art of SSA studies in the IC with the aim of contributing to the growing interest in the single-neuron electrophysiology of auditory deviance detection. The dependence of neuronal SSA on various stimulus features, e.g., probability of the deviant stimulus and repetition rate, and the roles of the AC and inhibition in shaping SSA at the level of the IC are addressed.
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影响因子：
3.5
作者：
Ayala YA;Pérez-González D;Duque D;Nelken I;Malmierca MS
通讯作者：
Malmierca MS
影响因子：
1.6
作者：
Eriksson, J;Villa, AEP
通讯作者：
Villa, AEP
影响因子：
5.7
作者：
Garagnani, Max;Pulvermueller, Friedemann
通讯作者：
Pulvermueller, Friedemann
影响因子：
3
作者：
Grimm, Sabine;Escera, Caries
通讯作者：
Escera, Caries
影响因子：
3.4
作者：
Anderson, L. A.;Malmierca, M. S.
通讯作者：
Malmierca, M. S.