Trends in parasite prevalence following 13 years of malaria interventions on Bioko island, Equatorial Guinea: 2004-2016.
Trends in parasite prevalence following 13 years of malaria interventions on Bioko island, Equatorial Guinea: 2004-2016.
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DOI：
10.1186/s12936-018-2213-9
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发表时间：
2018-02-05
期刊：
影响因子：
3
通讯作者：
Kleinschmidt I
中科院分区：
文献类型：
--
作者：
Cook J;Hergott D;Phiri W;Rivas MR;Bradley J;Segura L;Garcia G;Schwabe C;Kleinschmidt I
尽管过去十年疟疾传播大幅减少，但西非和中非许多国家的疟疾负担仍然很高。监测和评估疟疾传播趋势和干预策略是疟疾控制规划的关键要素。本研究使用年度疟疾指标调查的时间序列来跟踪赤道几内亚比奥科岛在 13 年强化干预期间的疟疾控制进展。 2004 年至 2016 年，在全岛 18 个哨点进行的横断面家庭调查中，每年对儿童（1 至 14 岁）的疟疾感染和血红蛋白进行测量。评估了传播模式的趋势，并评估了病媒控制干预措施（净使用和喷洒覆盖率）的影响。 2004 年至 2016 年间，使用快速诊断测试进行了大约 106,500 次寄生虫血症个体测试。尽管在此期间喷雾覆盖率仍然相对较高 (> 70%)，但报告的净使用量普遍低于 40%。 2004 年至 2016 年间，寄生虫患病率从 43.3% 降至 10.5%。1-5 岁儿童中度至重度贫血的患病率从 14.9% 降至 1.6%。 2004 年至 2016 年间，各个地点的寄生虫流行率降低了 57% 至 100%。睡在蚊帐下和住在过去 12 个月喷过杀虫剂的房子里可以独立预防感染（OR = 0.69 [95% CI 0.61–0.80] 和 OR = 0.87 [95% CI 0.78–0.97]，分别），而最近前往大陆的旅行使感染几率增加了近四倍（OR = 3.94 [95%CI 2.79–5.56]）。全岛范围内的干预措施使比奥科岛上的疟疾传播大幅减少。这一独特的时间序列连续 13 次年度疟疾指标调查清楚地表明了持续使用两种病媒控制干预措施（室内滞留喷洒和 LLIN）的长期有效性，以及全面和持续监测的价值。尽管在减轻岛上负担方面取得了相当大的成功，但疟疾仍然流行，一些地区的人口仍然面临很高的感染风险。本文的在线版本 (10.1186/s12936-018-2213-9) 包含补充材料，可供授权用户使用。
Whilst there have been substantial reductions in malaria transmission over the past decade, in many countries in West and Central Africa the malaria burden remains high. Monitoring and evaluation of malaria transmission trends and intervention strategies are key elements for malaria control programmes. This study uses a time series of annual malaria indicator surveys to track the progress of malaria control in Bioko Island, Equatorial Guinea, over a 13 year period of intensive interventions. Malaria infection and haemoglobin were measured annually in children (1 to 14 years) in cross-sectional household surveys from 2004 to 2016 in 18 sentinel sites across the island. Trends in transmission patterns were assessed and the impact of the vector control interventions (net use and spray coverage) was evaluated. Between 2004 and 2016 approximately 106,500 individual tests for parasitaemia were conducted using rapid diagnostic tests. Although spray coverage remained relatively high (> 70%) over the time period, reported net usage was generally below 40%. Parasite prevalence reduced from 43.3 to 10.5% between 2004 and 2016. The prevalence of moderate to severe anaemia in children aged 1–5 years reduced from 14.9 to 1.6%. Impact in individual sites ranged from 57 to 100% reductions in parasite prevalence between 2004 and 2016. Sleeping under a net and living in a house that had been sprayed in the past 12 months were independently protective against infection (OR = 0.69 [95%CI 0.61–0.80] and OR = 0.87 [95% CI 0.78–0.97], respectively), whilst recent travel to the mainland increased the odds of infection nearly fourfold (OR = 3.94 [95%CI 2.79–5.56]). Island-wide interventions have resulted in a substantial reduction in malaria transmission on Bioko Island. This unique time series of 13 consecutive annual malaria indicator surveys clearly demonstrates the long-term effectiveness of the sustained use of two vector control interventions, indoor residual spraying and LLINs, and the value of comprehensive and sustained surveillance. Despite considerable success in reducing the burden on the island, malaria is still endemic, with populations in some areas remaining at high risk of infection. The online version of this article (10.1186/s12936-018-2213-9) contains supplementary material, which is available to authorized users.
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影响因子：
3
作者：
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DOI：
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DOI：
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发表时间：
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影响因子：
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