Diagnostic accuracy of blood eosinophils in comparison to other common biomarkers for identifying sputum eosinophilia in patients with chronic cough.
Diagnostic accuracy of blood eosinophils in comparison to other common biomarkers for identifying sputum eosinophilia in patients with chronic cough.
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DOI：
10.1016/j.waojou.2023.100819
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发表时间：
2023-09
影响因子：
5.1
通讯作者：
Lai, Kefang
中科院分区：
文献类型：
--
作者：
Yi, Fang;Fang, Zhangfu;Liang, Hanwen;Huang, Lianrong;Jiang, Mei;Feng, Zien;Xiang, Keheng;Chen, Zhe;Luo, Wei;Lai, Kefang
痰液嗜酸性粒细胞增多是慢性咳嗽的一个可治疗特征。目前尚不清楚血液嗜酸性粒细胞计数是否可以用于识别慢性咳嗽患者的痰液嗜酸性粒细胞增多。本研究旨在评估血液嗜酸性粒细胞与其他常见 2 型生物标志物相比的诊断准确性，以识别慢性咳嗽患者的痰液嗜酸性粒细胞增多。在这项前瞻性研究中，共有 658 名慢性咳嗽患者入组。检测诱导痰试验、血常规、总免疫球蛋白 E (TIgE) 和呼出一氧化氮 (FeNO) 水平。痰嗜酸性粒细胞百分比（Eos%）≥2.5%定义为痰嗜酸性粒细胞增多。分析了单独或组合用于预测痰嗜酸性粒细胞增多的血液嗜酸性粒细胞计数、TIgE 和 FeNO 的曲线下面积 (AUC)。与 FeNO [0.784 (0.720–0.849)，P = 0.280] 和 TIgE [0.686 (0.613–0.760) 相比，血嗜酸性粒细胞计数预测慢性咳嗽患者痰液嗜酸性粒细胞增多的 AUC 适中 [0.826 (0.767–0.885)]， P = 0.001]。当结合血液嗜酸性粒细胞计数和 FeNO 来检测痰嗜酸性粒细胞增多时，与单独使用单个标记物相比，产生了显着更大的 AUC [0.868 (0.814–0.923)，敏感性为 84.2%，特异性为 82.8%]（所有 P < 0.05）。血液嗜酸性粒细胞计数对于识别慢性咳嗽患者的痰液嗜酸性粒细胞增多具有中等诊断价值，而血液嗜酸性粒细胞计数和 FeNO 测量的结合可以提供额外的预测价值。
Sputum eosinophilia is a treatable trait for chronic cough. It is currently not clear whether the blood eosinophil counts could be used to identify sputum eosinophilia in patients with chronic cough. This study aimed to evaluate the diagnostic accuracy of blood eosinophils in comparison to other common type 2 biomarkers for identifying sputum eosinophilia in patients with chronic cough. In this prospective study, a total of 658 patients with chronic cough were enrolled. Induced-sputum test, routine blood test, total immunoglobulin E (TIgE), and fractional exhaled nitric oxide (FeNO) level were measured. The percentage of sputum eosinophils (Eos%) ≥ 2.5% was defined as sputum eosinophilia. The area under the curve (AUC) of blood eosinophil counts, TIgE, and FeNO alone or in combination for predicting sputum eosinophilia were analyzed. The AUC of blood eosinophil counts for predicting sputum eosinophilia in chronic cough patients was moderate [0.826 (0.767–0.885)], as compared to that of FeNO [0.784 (0.720–0.849), P = 0.280] and TIgE [0.686 (0.613–0.760), P = 0.001]. When combining blood eosinophil counts and FeNO for detecting sputum eosinophilia, a significantly larger AUC [0.868 (0.814–0.923), with a sensitivity of 84.2% and a specificity of 82.8%] was yielded, as compared to each single marker alone (all P < 0.05). Blood eosinophil counts have a moderate diagnostic value for identifying sputum eosinophilia in patients with chronic cough, while a combination of blood eosinophil counts and FeNO measurement can provide additional predictive value.
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影响因子：
5
作者：
Sadeghi MH;Wright CE;Hart S;Crooks M;Morice AH
通讯作者：
Morice AH
DOI：
10.1164/rccm.200406-710st
发表时间：
2005-04-15
影响因子：
24.7
作者：
American Thoracic Society;European Respiratory Society
通讯作者：
European Respiratory Society
DOI：
10.1016/j.jaip.2019.12.019
发表时间：
2020-05-01
影响因子：
9.4
作者：
Caspard, Herve;Ambrose, Christopher S.;Zeiger, Robert S.
通讯作者：
Zeiger, Robert S.
Stard 2015：用于报告诊断准确性研究的基本项目的更新列表。
DOI：
10.1136/bmj.h5527
发表时间：
2015-10-28
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Bossuyt PM;Reitsma JB;Bruns DE;Gatsonis CA;Glasziou PP;Irwig L;Lijmer JG;Moher D;Rennie D;de Vet HC;Kressel HY;Rifai N;Golub RM;Altman DG;Hooft L;Korevaar DA;Cohen JF;STARD Group
通讯作者：
STARD Group
影响因子：
8.3
作者：
Chipps BE;Jarjour N;Calhoun WJ;Iqbal A;Haselkorn T;Yang M;Brumm J;Corren J;Holweg CTJ;Bafadhel M
通讯作者：
Bafadhel M