Does FeNO Predict Clinical Characteristics in Chronic Cough?
Does FeNO Predict Clinical Characteristics in Chronic Cough?
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DOI：
10.1007/s00408-017-0074-6
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发表时间：
2018-03
期刊：
影响因子：
5
通讯作者：
Morice AH
中科院分区：
文献类型：
--
作者：
Sadeghi MH;Wright CE;Hart S;Crooks M;Morice AH
评估呼出气一氧化氮测定是否有助于根据慢性咳嗽患者的气道炎症表型评估慢性咳嗽患者。我们研究了连续的病人参加专家咳嗽诊所。入选30例高FeNO患者（> 30 ppb）和20例低FeNO患者（< 20 ppb）。FeNO、B-Eos与痰嗜酸性粒细胞计数呈显著相关（p < 0.001）。低FeNO患者24小时内记录的咳嗽次数和HARQ评分显著较高（p < 0.05）。与高FeNO组（48%）相比，这些患者中女性比例更高（90%）。低FeNO组的LCQ评分更差，但不显著。观察到FeNO、血嗜酸性粒细胞和痰嗜酸性粒细胞之间存在强相关性，证实了表型同一性。观察到的性别差异是否解释了不同的咳嗽频率特征尚不清楚。
To evaluate whether exhaled nitric oxide measurement can facilitate in the assessment of chronic cough patients based on their airway inflammatory phenotype. We have studied consecutive patients attending a specialist cough clinic. 30 patients with high FeNO (> 30 ppb) and 20 patients with low FeNO (< 20 ppb) were recruited. There was a significant correlation between FeNO, B-Eos and sputum eosinophil count (p < 0.001). The number of recorded coughs in 24 h and HARQ scores were significantly (p < 0.05) higher in patients with a low FeNO. In contrast to the high FeNO group (48%), the greater proportion of these patients were women (90%). LCQ scores were worse in the low FeNO group but it was not significant. A strong relationship between FeNO, blood eosinophils and sputum eosinophils confirming phenotypic identity was observed. Whether the observed gender disparity accounts for the different cough frequency characteristics is unknown.
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DOI：
10.1186/1745-9974-2-8
发表时间：
2006-09-28
期刊：
Cough (London, England)
影响因子：
--
作者：
Barry, Samantha J;Dane, Adrie D;Morice, Alyn H;Walmsley, Anthony D
通讯作者：
Walmsley, Anthony D
DOI：
10.1164/rccm.200406-710st
发表时间：
2005-04-15
影响因子：
24.7
作者：
American Thoracic Society;European Respiratory Society
通讯作者：
European Respiratory Society
影响因子：
6.9
作者：
Fujimura, Masaki;Ohkura, Noriyuki;Hara, Johsuke
通讯作者：
Hara, Johsuke
影响因子：
10
作者：
Wagener, A. H.;de Nijs, S. B.;Sterk, P. J.
通讯作者：
Sterk, P. J.
影响因子：
10
作者：
Kelsall, A.;Decalmer, S.;Smith, J. A.
通讯作者：
Smith, J. A.