Characteristic Alterations of Network in Patients With Intraoperative Stimulation-Induced Seizures During Awake Craniotomy.
Characteristic Alterations of Network in Patients With Intraoperative Stimulation-Induced Seizures During Awake Craniotomy.
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DOI：
10.3389/fneur.2021.602716
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发表时间：
2021
影响因子：
3.4
通讯作者：
Jiang T
中科院分区：
文献类型：
--
作者：
Fang S;Zhou C;Wang L;Fan X;Wang Y;Zhang Z;Jiang T
背景：在清醒开颅手术中使用皮质电图（ECoG）来避免术中刺激诱发癫痫（ISS）是有争议的。虽然标准的直接皮层刺激（DCS）协议用于识别功能皮层和皮层下结构，ISS仍然发生。癫痫与大脑网络的改变有关。在这项研究中，我们调查了ISS患者大脑网络的特定改变。方法：27例脑胶质瘤患者根据ISS发生史分为ISS组和非ISS组。在清醒开颅术期间使用标准DCS方案，无需ECoG监督。图形理论测量被用来分析静息态功能磁共振成像数据，以定量地揭示功能网络的变化。结果如下：在感觉运动网络中，神经胶质瘤显著降低ISS组的四个边缘的功能连接性（FC），在多次校正后，非ISS组的FC反而增加（p <0.001，p值阈值= 0.002）。关于拓扑性质，所有参与者的感觉运动网络被归类为小世界网络。与非ISS组相比，神经胶质瘤显著增加了ISS组的整体效率、节点效率和sigma值，并降低了最短路径长度（p <0.05）。结论：特定的改变表明DCS期间患者对ISS的易感性增加了全局和节点效率，并降低了胶质瘤诱导的最短路径长度和FC。如果患者有这些特定的改变，建议ECoG在DCS期间监测放电后电流，以避免ISS。
Background: The use of electrocorticography (ECoG) to avoid intraoperative stimulation-induced seizure (ISS) during awake craniotomy is controversial. Although a standard direct cortical stimulating (DCS) protocol is used to identify the eloquent cortices and subcortical structures, ISS still occurs. Epilepsy is related to alterations in brain networks. In this study, we investigated specific alterations in brain networks in patients with ISS. Methods: Twenty-seven patients with glioma were enrolled and categorized into the ISS and non-ISS groups based on their history of ISS occurrence. A standard DCS protocol was used during awake craniotomy without ECoG supervision. Graph theoretical measurement was used to analyze resting-state functional magnetic resonance imaging data to quantitatively reveal alterations in the functional networks. Results: In the sensorimotor networks, the glioma significantly decreased the functional connectivity (FC) of four edges in the ISS group, which were conversely increased in the non-ISS group after multiple corrections (p < 0.001, threshold of p-value = 0.002). Regarding the topological properties, the sensorimotor network of all participants was classified as a small-world network. Glioma significantly increased global efficiency, nodal efficiency, and the sigma value, as well as decreased the shortest path length in the ISS group compared with the non-ISS group (p < 0.05). Conclusions: The specific alterations indicating patient susceptibility to ISS during DCS increased global and nodal efficiencies and decreased the shortest path length and FC induced by gliomas. If the patient has these specific alterations, ECoG is recommended to monitor after-discharge current during DCS to avoid ISS.
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DOI：
10.1093/cercor/bhw157
发表时间：
2016-08
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Fan L;Li H;Zhuo J;Zhang Y;Wang J;Chen L;Yang Z;Chu C;Xie S;Laird AR;Fox PT;Eickhoff SB;Yu C;Jiang T
通讯作者：
Jiang T
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影响因子：
3.5
作者：
Fang, S.;Liang, J.;Jiang, T.
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影响因子：
4.1
作者：
Hervey-Jumper, Shawn L.;Li, Jing;Berger, Mitchel S.
通讯作者：
Berger, Mitchel S.
影响因子：
4.1
作者：
Sartorius, CJ;Berger, MS
通讯作者：
Berger, MS
DOI：
10.1007/bf03009510
发表时间：
1993-05-01
期刊：
CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE
影响因子：
--
作者：
GIGNAC, E;MANNINEN, PH;GELB, AW
通讯作者：
GELB, AW