Hepcidin levels in diabetes mellitus and polycystic ovary syndrome.
Hepcidin levels in diabetes mellitus and polycystic ovary syndrome.
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DOI：
10.1111/dme.12262
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发表时间：
2013-12
期刊：
影响因子：
--
通讯作者：
Murphy KG
中科院分区：
文献类型：
--
作者：
Sam AH;Busbridge M;Amin A;Webber L;White D;Franks S;Martin NM;Sleeth M;Ismail NA;Daud NM;Papamargaritis D;Le Roux CW;Chapman RS;Frost G;Bloom SR;Murphy KG
体内铁的增加与胰岛素抵抗有关。铁调素是负调节铁稳态的关键激素。我们假设，胰岛素抵抗的个体铁调素水平不足，铁负荷不足。在患有2型糖尿病的参与者（n = 33，年龄、性别和BMI匹配的对照受试者，n = 33）和患有多囊卵巢综合征的参与者（n = 27，年龄和BMI匹配的对照受试者，n = 16）中评估了活性形式的铁调素（铁调素-25）和铁调素：铁蛋白比率的血清浓度。为了研究观察到的任何变化是否与胰岛素抵抗相关，而不是胰岛素缺乏或高血糖本身，对1型糖尿病参与者进行了相同的测量（n = 28，年龄，性别和BMI匹配的对照组，n = 30）。最后，在超重或肥胖的无糖尿病参与者（n = 16）中探讨了胰岛素抵抗的稳态模型评估与血清铁调素：铁蛋白比值之间的关系。2型糖尿病患者的铁调素和铁调素/铁蛋白比值显著低于对照组（分别为P < 0.05和P < 0.01）。多囊卵巢综合征患者的铁调素/铁蛋白比值显著低于对照组（P < 0.05）。1型糖尿病患者和对照组之间的铁调素或铁调素：铁蛋白比率没有显著差异（P = 0.88和P = 0.94）。血清铁调素/铁蛋白比值与稳态模型胰岛素抵抗评分呈负相关（r =-0.59，P < 0.05）。胰岛素抵抗与铁调素水平不足有关，但与胰岛素缺乏或高胰岛素血症本身无关。铁调素浓度降低可能导致胰岛素抵抗状态下体内铁储存增加。
Increased body iron is associated with insulin resistance. Hepcidin is the key hormone that negatively regulates iron homeostasis. We hypothesized that individuals with insulin resistance have inadequate hepcidin levels for their iron load. Serum concentrations of the active form of hepcidin (hepcidin-25) and hepcidin:ferritin ratio were evaluated in participants with Type 2 diabetes (n = 33, control subjects matched for age, gender and BMI,n = 33) and participants with polycystic ovary syndrome (n = 27, control subjects matched for age and BMI,n = 16). To investigate whether any changes observed were associated with insulin resistance rather than insulin deficiency or hyperglycaemia per se, the same measurements were made in participants with Type 1 diabetes (n = 28, control subjects matched for age, gender and BMI,n = 30). Finally, the relationship between homeostasis model assessment of insulin resistance and serum hepcidin:ferritin ratio was explored in overweight or obese participants without diabetes (n = 16). Participants with Type 2 diabetes had significantly lower hepcidin and hepcidin:ferritin ratio than control subjects (P < 0.05 and P < 0.01, respectively). Participants with polycystic ovary syndrome had a significantly lower hepcidin:ferritin ratio than control subjects (P < 0.05). There was no significant difference in hepcidin or hepcidin:ferritin ratio between participants with Type 1 diabetes and control subjects (P = 0.88 and P = 0.94). Serum hepcidin:ferritin ratio inversely correlated with homeostasis model assessment of insulin resistance (r = –0.59, P < 0.05). Insulin resistance, but not insulin deficiency or hyperglycaemia per se, is associated with inadequate hepcidin levels. Reduced hepcidin concentrations may cause increased body iron stores in insulin-resistant states.
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