Concise review: MicroRNA function in multipotent mesenchymal stromal cells.
Concise review: MicroRNA function in multipotent mesenchymal stromal cells.
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DOI：
10.1002/stem.1623
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发表时间：
2014-05
期刊：
影响因子：
5.2
通讯作者：
Fierro, Fernando A.
中科院分区：
文献类型：
--
作者：
Clark, Elizabeth A.;Kalomoiris, Stefanos;Nolta, Jan A.;Fierro, Fernando A.
多能间充质基质细胞（MSC）由于其简单的分离、广泛的扩增潜力和低免疫原性而成为不同细胞疗法的理想候选者。对于各种治疗方法，如骨和软骨修复，MSC预计通过直接分化来替代受损组织，而许多其他应用依赖于调节免疫应答和促进血管生成的旁分泌因子的分泌。靶向信使RNA进行切割或翻译抑制的微小RNA（miRNAs）最近已被证明在MSC中发挥关键功能，以调节分化、旁分泌活性和其他细胞特性，如增殖、存活和迁移。MSC的总体miRNA表达谱根据组织来源、物种和检测方法而变化，而某些miRNA也一致地存在于所有类型的MSC中。最近已经描述了超过60种不同的miRNAs在MSC中的功能，这是本文的主题。特别强调的是已经证明在体内MSC中的功能的miRNA。我们还详细介绍了具有重叠效应的miRNA（即，共同的靶基因）并讨论未来的方向，以加深我们对MSC中miRNA生物学的理解。这些最近的发现开启了在MSC中调节miRNAs的可能性，以增强其促再生的治疗潜力。
Multipotent mesenchymal stromal cells (MSCs) are ideal candidates for different cellular therapies due to their simple isolation, extensive expansion potential, and low immunogenicity. For various therapeutic approaches, such as bone and cartilage repair, MSCs are expected to contribute by direct differentiation to replace the damaged tissue, while many other applications rely on the secretion of paracrine factors which modulate the immune response and promote angiogenesis. MicroRNAs (miRNAs), which target messenger RNA for cleavage or translational repression, have recently been shown to play critical functions in MSC to regulate differentiation, paracrine activity, and other cellular properties such as proliferation, survival, and migration. The global miRNA expression profile of MSC varies according to the tissue of origin, species, and detection methodology, while also certain miRNAs are consistently found in all types of MSC. The function in MSC of more than 60 different miRNAs has been recently described, which is the subject of this review. A special emphasis is given to miRNAs that have demonstrated a function in MSC in vivo. We also present in detail miRNAs with overlapping effects (i.e., common target genes) and discuss future directions to deepen our understanding of miRNA biology in MSC. These recent discoveries have opened the possibility of modulating miRNAs in MSC, in order to enhance their proregenerative, therapeutic potential.
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