Cellular infiltration in traumatic brain injury.
Cellular infiltration in traumatic brain injury.
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DOI：
10.1186/s12974-020-02005-x
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发表时间：
2020-11-03
影响因子：
9.3
通讯作者：
Helmy A
中科院分区：
文献类型：
--
作者：
Alam A;Thelin EP;Tajsic T;Khan DZ;Khellaf A;Patani R;Helmy A
创伤性脑损伤导致细胞损伤，这反过来导致损伤相关分子模式（DAMP）的快速释放，其促使驻留细胞释放细胞因子和趋化因子。这些反过来又迅速招募中性粒细胞，这有助于限制损伤的扩散和清除细胞碎片。小胶质细胞持续地调查CNS（中枢神经系统）隔室，并识别有助于反应的神经元中的结构异常。几天后，当中性粒细胞数量开始下降时，激活的小胶质细胞和星形胶质细胞在损伤部位聚集-将损伤组织与健康组织分离并促进恢复过程。单核细胞浸润损伤部位以产生趋化因子，所述趋化因子募集星形胶质细胞，所述星形胶质细胞在恢复期期间连续地将它们的过程向单核细胞延伸。以这种方式，单核细胞浸润有助于修复受损的大脑。神经元和星形胶质细胞也通过下调细胞毒性炎症来缓和脑炎症。根据脑损伤的严重程度，T和B细胞也可以在稍后的时间点被募集到脑病理学部位。
Traumatic brain injury leads to cellular damage which in turn results in the rapid release of damage-associated molecular patterns (DAMPs) that prompt resident cells to release cytokines and chemokines. These in turn rapidly recruit neutrophils, which assist in limiting the spread of injury and removing cellular debris. Microglia continuously survey the CNS (central nervous system) compartment and identify structural abnormalities in neurons contributing to the response. After some days, when neutrophil numbers start to decline, activated microglia and astrocytes assemble at the injury site—segregating injured tissue from healthy tissue and facilitating restorative processes. Monocytes infiltrate the injury site to produce chemokines that recruit astrocytes which successively extend their processes towards monocytes during the recovery phase. In this fashion, monocytes infiltration serves to help repair the injured brain. Neurons and astrocytes also moderate brain inflammation via downregulation of cytotoxic inflammation. Depending on the severity of the brain injury, T and B cells can also be recruited to the brain pathology sites at later time points.
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DOI：
10.1523/jneurosci.5399-12.2013
发表时间：
2013-04-03
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bachstetter AD;Rowe RK;Kaneko M;Goulding D;Lifshitz J;Van Eldik LJ
通讯作者：
Van Eldik LJ
影响因子：
5.3
作者：
Beattie, MS;Bresnahan, JC;Young, W
通讯作者：
Young, W
影响因子：
3.9
作者：
Block, M. L.;Hong, J. -S.
通讯作者：
Hong, J. -S.
影响因子：
5.5
作者：
Carlos, TM;Clark, RSB;Kochanekt, PM
通讯作者：
Kochanekt, PM
影响因子：
15.1
作者：
Al Nimer, Faiez;Lindblom, Rickard;Piehl, Fredrik
通讯作者：
Piehl, Fredrik