Non-small cell lung cancer at the extremes of age: impact on diagnosis and treatment.
Non-small cell lung cancer at the extremes of age: impact on diagnosis and treatment.
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极端年龄的非小细胞肺癌：对诊断和治疗的影响。
DOI：
10.1016/s0003-4975(96)00745-x
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Rigas,JR
中科院分区：
文献类型：
--
作者：
Nugent,WC;Edney,MT;Hammerness,PG;Dain,BJ;Maurer,LH;Rigas,JR
背景早期发现和手术切除为肺癌患者提供了最高的治愈可能性。极端年龄的患者可能无法从这些干预措施中获得最大利益。为了研究年龄对非小细胞肺癌患者的分期、组织学、症状和治疗的影响，我们进行了回顾性研究。方法1983年至1993年期间确定了1802名非小细胞肺癌患者。按年龄选择患者，分为45岁以下（55例）和80岁以上（108例），并回顾了他们的病历。结果3名年轻患者（6%） 患有 I 期或 II 期疾病，但仍有 15 人（32%）接受了胸部手术。 27 名老年患者（33%）处于早期疾病阶段，只有 6% 接受了手术。对于可手术切除的疾病分期（I 期至 IIIA 期）的年轻人群，中位生存期显着较长（p < 0.05），而对于晚期疾病（IIIB 期和 IV 期）的两组，生存期没有显着差异。 结论 年龄显着影响非小细胞肺癌患者的表现和治疗。尽管胸腔手术具有最大的生存优势，但由于年轻患者的疾病进展和老年人缺乏手术干预，这种优势会减弱。 （安胸外科 1997 年；63：193–7）
BackgroundEarly detection and surgical resection offers the highest likelihood of cure for patients with lung cancer. Patients presenting at the extremes of age may fail to benefit maximally from these interventions. To study the impact of age on stage, histology, symptom, and treatment of patients with non–small cell lung cancer, we undertook a retrospective review.MethodsOne thousand eight hundred two patients with non–small cell lung cancer were identified between 1983 and 1993. Patients were selected by age as less than 45 years (55 patients) and 80 years or more (108 patients), and their medical records were reviewed.ResultsThree younger patients (6%) presented with stage I or II disease, yet 15 (32%) underwent thoracic operation. Twenty-seven elderly patients (33%) presented with early stage disease and only 6% underwent operation. The median survival was significantly longer for the younger population with surgically resectable stages of disease (stage I to IIIA) (p < 0.05), whereas no significant difference in survival was seen for the two groups with advanced disease (stage IIIB and IV).ConclusionsAge significantly affects the presentation and treatment of non–small cell lung cancer patients. Although thoracic operation imparts the greatest survival advantage, this benefit is diminished due to advanced disease in the younger patients and lack of surgical intervention in the elderly. (Ann Thorac Surg 1997;63:193–7)
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手术在 N2 肺癌中的作用。
DOI：
10.1016/s0039-6109(16)44341-0
发表时间：
1987
期刊：
The Surgical clinics of North America
影响因子：
--
作者：
N. Martini;B. Flehinger
通讯作者：
B. Flehinger
影响因子：
10.3
作者：
Zang, EA;Wynder, EL
通讯作者：
Wynder, EL
DOI：
10.1016/s0022-5223(19)37271-x
发表时间：
1982-03
期刊：
The Journal of thoracic and cardiovascular surgery
影响因子：
--
作者：
L. Decaro;J. Benfield
通讯作者：
L. Decaro;J. Benfield
影响因子：
4.5
作者：
LAM, KY;FU, KH;WANG, EP
通讯作者：
WANG, EP
影响因子：
4.6
作者：
PEMBERTON, JH;NAGORNEY, DM;BERNATZ, PE
通讯作者：
BERNATZ, PE