The coagulation system in host defense.

The coagulation system in host defense.
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DOI:
10.1002/rth2.12109
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发表时间:
2018-07
影响因子:
4.6
通讯作者:
Antoniak S
Antoniak S
中科院分区:
医学2区
文献类型:
--
作者:
Antoniak S

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高等生物的凝血系统和免疫系统被认为具有共同的祖先起源。在感染期间,凝血系统被激活,止血系统的组分直接参与免疫应答和免疫系统调节。目前的观点是,凝血的激活对细菌和病毒感染是有益的。它限制病原体传播并支持病原体杀灭和组织修复。另一方面,过度激活可导致血栓形成,随后会耗尽止血因子和继发性出血。本文将总结目前的知识,凝血和病原体感染的重点是最新的研究中的作用,血液凝固系统的不同部分在选定的细菌和病毒感染。
The blood coagulation system and immune system of higher organisms are thought to have a common ancestral origin. During infections, the blood coagulation system is activated and components of the hemostatic system are directly involved in the immune response and immune system modulations. The current view is that the activation of coagulation is beneficial for infections with bacteria and viruses. It limits pathogen dissemination and supports pathogen killing and tissue repair. On the other hand, over‐activation can lead to thrombosis with subsequent depletion of hemostatic factors and secondary bleeding. This review will summarize the current knowledge on blood coagulation and pathogen infection with focus on most recent studies of the role of the different parts of the blood coagulation system in selected bacterial and viral infections.
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