Disease-free survival after hepatic resection in hepatocellular carcinoma patients: a prediction approach using artificial neural network.
Disease-free survival after hepatic resection in hepatocellular carcinoma patients: a prediction approach using artificial neural network.
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DOI：
10.1371/journal.pone.0029179
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Chiu HC
中科院分区：
文献类型：
--
作者：
Ho WH;Lee KT;Chen HY;Ho TW;Chiu HC
使用接受肝切除术的肝细胞癌（HCC）患者的数据库，基于该患者组的一组临床参数，开发1年、3年和5年无病生存率的预测模型。三种预测模型包括人工神经网络（ANN）模型、逻辑回归（LR）模型和决策树（DT）模型。从HCC患者数据库中分别提取了427、354和297例肝切除术后1年、3年和5年无病生存的HCC患者的数据。从三组中的每一组中，选择80%的病例（分别为342、283和238例1年、3年和5年无病生存）为预测模型提供训练数据。每组中剩余的20%的病例（三个相应组中的85、71和59例病例）被分配到验证组，用于三个模型的性能比较。以受试者工作特征曲线下面积（AUROC）作为评价三种模型的性能指标。ANN模型在预测精度方面优于LR和DT模型。这项研究证明了在医疗决策支持系统中使用人工神经网络的可行性，该系统基于接受肝切除术的HCC患者的临床数据库预测无病生存期。
A database for hepatocellular carcinoma (HCC) patients who had received hepatic resection was used to develop prediction models for 1-, 3- and 5-year disease-free survival based on a set of clinical parameters for this patient group. The three prediction models included an artificial neural network (ANN) model, a logistic regression (LR) model, and a decision tree (DT) model. Data for 427, 354 and 297 HCC patients with histories of 1-, 3- and 5-year disease-free survival after hepatic resection, respectively, were extracted from the HCC patient database. From each of the three groups, 80% of the cases (342, 283 and 238 cases of 1-, 3- and 5-year disease-free survival, respectively) were selected to provide training data for the prediction models. The remaining 20% of cases in each group (85, 71 and 59 cases in the three respective groups) were assigned to validation groups for performance comparisons of the three models. Area under receiver operating characteristics curve (AUROC) was used as the performance index for evaluating the three models. The ANN model outperformed the LR and DT models in terms of prediction accuracy. This study demonstrated the feasibility of using ANNs in medical decision support systems for predicting disease-free survival based on clinical databases in HCC patients who have received hepatic resection.
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