Malignant pleural effusion: Updates in diagnosis, management and current challenges.

Malignant pleural effusion: Updates in diagnosis, management and current challenges.
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DOI:
10.3389/fonc.2022.1053574
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发表时间:
2022
影响因子:
4.7
通讯作者:
Rahman, Najib M.
Rahman, Najib M.
中科院分区:
医学3区
文献类型:
--
作者:
Addala, Dinesh Narayan;Kanellakis, Nikolaos I.;Bedawi, Eihab O.;Dong, Tao;Rahman, Najib M.

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恶性胸腔积液(MPE)是一种常见的疾病,通常会导致患者出现严重症状,并给医疗保健系统带来成本。在过去的十年中,MPE的管理取得了巨大的进展,大规模的随机试验回答了有关最佳诊断策略和有效管理策略的关键问题。尽管有许多治疗选择,包括滑石粉胸膜固定术,留置胸膜导管和两者的组合,MPE的治疗仍然以症状为导向,以引流策略为中心。为患者提供更好的护理的未来目标在于根据恶性肿瘤类型和生存率的概率,将治疗模式从通用途径转变为个性化护理。本文综述了MPE诊断和治疗的现有证据基础、新发现和未来发展方向。
Malignant pleural effusion (MPE) is a common condition which often causes significant symptoms to patients and costs to healthcare systems. Over the past decade, the management of MPE has progressed enormously with large scale, randomised trials answering key questions regarding optimal diagnostic strategies and effective management strategies. Despite a number of management options, including talc pleurodesis, indwelling pleural catheters and combinations of the two, treatment for MPE remains symptom directed and centered around drainage strategy. The future goals for providing improved care for patients lies in changing the treatment paradigm from a generic pathway to personalised care, based on probability of malignancy type and survival. This article reviews the current evidence base, new discoveries and future directions in the diagnosis and management of MPE.
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