Immune Responses to Influenza Virus and Its Correlation to Age and Inherited Factors.
Immune Responses to Influenza Virus and Its Correlation to Age and Inherited Factors.
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DOI：
10.3389/fmicb.2016.01841
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发表时间：
2016
影响因子：
5.2
通讯作者：
Sekaran SD
中科院分区：
文献类型：
--
作者：
Bahadoran A;Lee SH;Wang SM;Manikam R;Rajarajeswaran J;Raju CS;Sekaran SD
流感病毒属于包膜病毒的正黏液病毒科，是全世界呼吸道感染的重要病因。流感病毒能够感染各种各样的物种，如家禽、海洋动物、猪、马和人类。在流感病毒感染后，先天免疫在有效和快速控制病毒感染以及启动适应性免疫方面起着关键作用。体液免疫系统产生针对不同流感抗原的抗体，其中ha特异性抗体对中和病毒从而预防疾病最为重要。包括CD4+辅助性T细胞和CD8+细胞毒性T细胞在内的细胞介导免疫是流感病毒感染诱导的适应性免疫的另一个分支。复杂的遗传因素和年龄相关的变化与宿主免疫反应有关。在此，我们回顾了流感病毒免疫反应的不同组成部分。此外，还讨论了免疫反应与年龄和遗传因素的相关性。这些确定有助于更好地了解开发改良疫苗以控制流感病毒感染的免疫反应的局限性。
Influenza viruses belong to the family Orthomyxoviridae of enveloped viruses and are an important cause of respiratory infections worldwide. The influenza virus is able to infect a wide variety species as diverse as poultry, marine, pigs, horses, and humans. Upon infection with influenza virus the innate immunity plays a critical role in efficient and rapid control of viral infections as well as in adaptive immunity initiation. The humoral immune system produces antibodies against different influenza antigens, of which the HA-specific antibody is the most important for neutralization of the virus and thus prevention of illness. Cell mediated immunity including CD4+ helper T cells and CD8+ cytotoxic T cells are the other arms of adaptive immunity induced upon influenza virus infection. The complex inherited factors and age related changes are associated with the host immune responses. Here, we review the different components of immune responses against influenza virus. Additionally, the correlation of the immune response to age and inherited factors has been discussed. These determinations lead to a better understanding of the limitations of immune responses for developing improved vaccines to control influenza virus infection.
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DOI：
10.1084/jem.20090896
发表时间：
2009-08-31
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Agius E;Lacy KE;Vukmanovic-Stejic M;Jagger AL;Papageorgiou AP;Hall S;Reed JR;Curnow SJ;Fuentes-Duculan J;Buckley CD;Salmon M;Taams LS;Krueger J;Greenwood J;Klein N;Rustin MH;Akbar AN
通讯作者：
Akbar AN
影响因子：
5.3
作者：
Boehmer, ED;Meehan, MJ;Kovacs, EJ
通讯作者：
Kovacs, EJ
影响因子：
4.8
作者：
Cummins, Nathan W.;Weaver, Eric A.;Badley, Andrew D.
通讯作者：
Badley, Andrew D.
影响因子：
5.4
作者：
Bot, A;Bot, S;Bona, CA
通讯作者：
Bona, CA
DOI：
10.4049/jimmunol.182.2.784
发表时间：
2009-01-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Ahmed M;Lanzer KG;Yager EJ;Adams PS;Johnson LL;Blackman MA
通讯作者：
Blackman MA