Melanin-Based Contrast Agents for Biomedical Optoacoustic Imaging and Theranostic Applications.
Melanin-Based Contrast Agents for Biomedical Optoacoustic Imaging and Theranostic Applications.
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DOI：
10.3390/ijms18081719
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发表时间：
2017-08-07
影响因子：
5.6
通讯作者：
Oraevsky A
中科院分区：
文献类型：
--
作者：
Longo DL;Stefania R;Aime S;Oraevsky A
光声成像出现于20世纪90年代初，是一种新的生物医学成像技术，它通过用短激光脉冲照射组织并检测产生的超声波来生成图像。该技术利用分子成像的光谱方法，并在组织深度提供高分辨率图像。光声成像的分辨率是可扩展的，因此可以可视化从细胞器到大型器官的生物医学系统，并且更重要的是，基于其光学吸收系数来表征，该光学吸收系数与吸收发色团的浓度成比例。光声成像被证明在使用小动物模型的临床前研究和临床应用中是有用的。分子成像领域的应用为开发用于定量光声成像的高度特异性和有效的造影剂提供了大量机会。最近的努力正在无毒的生物可降解的造影剂（如黑色素制成的纳米粒子）的方向，有可能适用于临床光声成像。为了提高造影剂和探针的效率和特异性，需要使它们变得智能并且能够在靶细胞中受控积累。这篇综述是为了认识到有效和无毒的基于黑色素的光声造影剂可以实现医学光声成像的潜在突破。
Optoacoustic imaging emerged in early 1990s as a new biomedical imaging technology that generates images by illuminating tissues with short laser pulses and detecting resulting ultrasound waves. This technique takes advantage of the spectroscopic approach to molecular imaging, and delivers high-resolution images in the depth of tissue. Resolution of the optoacoustic imaging is scalable, so that biomedical systems from cellular organelles to large organs can be visualized and, more importantly, characterized based on their optical absorption coefficient, which is proportional to the concentration of absorbing chromophores. Optoacoustic imaging was shown to be useful in both preclinical research using small animal models and in clinical applications. Applications in the field of molecular imaging offer abundant opportunities for the development of highly specific and effective contrast agents for quantitative optoacoustic imaging. Recent efforts are being made in the direction of nontoxic biodegradable contrast agents (such as nanoparticles made of melanin) that are potentially applicable in clinical optoacoustic imaging. In order to increase the efficiency and specificity of contrast agents and probes, they need to be made smart and capable of controlled accumulation in the target cells. This review was written in recognition of the potential breakthroughs in medical optoacoustic imaging that can be enabled by efficient and nontoxic melanin-based optoacoustic contrast agents.
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影响因子：
17.1
作者：
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影响因子：
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Aime, Silvio
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影响因子：
13.3
作者：
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影响因子：
17.1
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影响因子：
11.2
作者：
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通讯作者：
Gillies RJ