Effect of triclosan on the subgingival microbiota of periodontitis-susceptible subjects.
Effect of triclosan on the subgingival microbiota of periodontitis-susceptible subjects.
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三氯生对牙周炎易感受试者龈下微生物群的影响。
DOI：
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发表时间：
1997
影响因子：
6.7
通讯作者：
J. Lindhe
中科院分区：
文献类型：
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作者：
B. Rosling;G. Dahle;A. R. Volpe;Y. Furuichi;P. Ramberg;J. Lindhe
本研究评估了以下两种方法的长期效果：(1)严格自我控制龈上菌斑；(2)在易患破坏性牙周炎的成人受试者中使用含有三氯生/共聚物的牙膏。40个人被招募到试验中。在基线检查前3-5年，他们都接受过非手术治疗-治疗晚期牙周病。在随后的维持阶段，所有受试者在不同的时间间隔表现出复发性牙周炎的部位。在基线检查时，检查每颗牙齿的6个表面，检查探针出血、探针袋深度和探针附着水平。选择每个象限最深的袋状部位（即每个受试者4个部位）并采集龈下细菌样本。在基线时，所有志愿者都获得了适当口腔卫生技术的详细信息。在随后的36个月期间，根据个人需要重复提供了这些资料。在基线和36个月检查之间没有提供专业的龈下治疗。受试者随机分为2组，每组20人，试验组1人，对照组1人。试验组的成员使用含三氯生/共聚物的含氟牙膏（Total, Colgate），而对照组使用相应的牙膏，但不含三氯生/共聚物。研究结果表明，在患有晚期和复发性牙周炎的受试者中，仔细练习龈上菌斑控制对龈下微生物群有一定影响，但这也不足以预防疾病进展。然而，在相应的一组受试者中，使用三氯生/共聚物牙膏，龈下微生物群在定量和定性方面都有所减少，复发性牙周炎几乎完全被预防。
The present study evaluated the long-term effect of (i) meticulous self-performed, supragingival plaque control and (ii) the use of a triclosan/copolymer containing dentifrice in adult subjects susceptible to destructive periodontitis. 40 individuals were recruited into the trial. 3-5 years prior to the baseline examination, they had all been treated by nonsurgical means- for advanced periodontal disease. During the subsequent maintenance phase, all subjects had at different time intervals exhibited sites with recurrent periodontitis. At a baseline examination, 6 surfaces per tooth were examined regarding bleeding on probing, probing pocket depth, and probing attachment level. The deepest pocket site in each quadrant (i.e. 4 sites per subject) was selected and samples of the subgingival bacteria were taken. At baseline, all volunteers received detailed information on proper oral hygiene techniques. This information was repeated on an individual need basis during the course of the subsequent 36-months. No professional subgingival therapy was delivered between the baseline and the 36-month examinations. The subjects were randomly distributed into 2 equal groups of 20 individuals each, 1 test and 1 control group. The members of the test group were supplied with a fluoridated dentifrice containing triclosan/copolymer (Total, Colgate), while the controls received a corresponding dentifrice but without triclosan/copolymer. The findings demonstrated that in subjects with advanced and recurrent periodontitis, carefully practiced supragingival plaque control had some effects on the subgingival microbiota, but also that this was insufficient to prevent disease progression. In a corresponding group of subjects, however, who used a triclosan/copolymer dentifrice, the subgingival microbiota was reduced in both quantitative and qualitative terms and recurrent periodontitis was almost entirely prevented.
改良维德曼皮瓣手术和全身四环素对牙周病变龈下微生物群的影响。
影响因子：
6.7
作者：
Haffajee,AD;Dzink,JL;Socransky,SS
通讯作者：
Socransky,SS