Effect of gestational hypercholesterolemia and maternal immunization on offspring plasma eicosanoids.
Effect of gestational hypercholesterolemia and maternal immunization on offspring plasma eicosanoids.
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DOI：
10.1016/j.ajog.2011.03.044
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发表时间：
2011-08
影响因子：
9.8
通讯作者：
Palinski W
中科院分区：
文献类型：
--
作者：
Quehenberger O;Yamashita T;Armando AM;Dennis EA;Palinski W
母体在怀孕前用氧化低密度脂蛋白免疫可以防止妊娠期高胆固醇血症引起的子宫内致病性编程，但妊娠期高胆固醇血症和母体免疫是否影响类似的途径尚不清楚。使用脂质组学方法在免疫和非免疫正常或高胆固醇血症兔母亲的成年后代中进行无偏倚的血浆类花生酸谱分析。吉西他滨高胆固醇血症与仅通过环氧合酶和12-脂氧合酶途径形成的某些类花生酸水平升高相关（包括TXB 2、PGF 2 α、PGE 2和PGD 2）。高胆固醇血症或正常胆固醇血症母亲的免疫减少了环氧合酶途径的14种类花生酸中的9种，5-和12-脂氧合酶途径的23种类花生酸中的21种（例如5-HETE，HXB 3，12-HETE），细胞色素P-450途径的19种类花生酸中的8种以及非酶途径的所有代谢物。母体免疫不仅抵消妊娠期高胆固醇血症在子宫内编程，但减少了广泛的类花生酸免疫和炎症调节剂的后代。
Maternal immunization with oxidized low-density-lipoprotein prior to pregnancy prevents pathogenic in utero programming by gestational hypercholesterolemia, but it is unknown whether gestational hypercholesterolemia and maternal immunization affect similar pathways. A lipidomic approach was used for unbiased plasma eicosanoid profiling in adult offspring of immunized and non-immunized normo- or hypercholesterolemic rabbit mothers. Gestational hypercholesterolemia was associated with increased levels of some eicosanoids formed by the cyclooxygenase and 12-lipoxygenase pathways only (including TXB2, PGF2α, PGE2, and PGD2). Immunization of hypercholesterolemic or normocholesterolemic mothers reduced 9 of 14 eicosanoids of the cyclooxygenase pathway, 21 of 23 eicosanoids of the 5- and 12-lipoxygenase pathways (e.g. 5-HETE, HXB3, 12-HETE), 8 of 19 eicosanoids of the cytochrome P-450 pathway and all metabolites of the nonenzymatic pathway. Maternal immunization not only counteracts in utero programming by gestational hypercholesterolemia but reduces a broad range of eicosanoid modulators of immunity and inflammation in offspring.
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影响因子：
37.8
作者：
Napoli, C;Witztum, JL;Palinski, W
通讯作者：
Palinski, W
DOI：
10.1161/01.atv.0000282193.31936.fd
发表时间：
2007-10-01
影响因子：
8.7
作者：
Alkemade, Fanneke E.;Gittenberger-de Groot, Adriana C.;DeRuiter, Marco C.
通讯作者：
DeRuiter, Marco C.
影响因子：
37.8
作者：
Huo, YQ;Zhao, L;Ley, K
通讯作者：
Ley, K
影响因子：
37.8
作者：
Khan, I;Dekou, V;Taylor, P
通讯作者：
Taylor, P
DOI：
10.4049/jimmunol.0901499
发表时间：
2009-11-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Blaho VA;Buczynski MW;Dennis EA;Brown CR
通讯作者：
Brown CR