Idiopathic Hypoparathyroidism With Papillary Thyroid Carcinoma in a Young Male: A Rare Case Report.
Idiopathic Hypoparathyroidism With Papillary Thyroid Carcinoma in a Young Male: A Rare Case Report.
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年轻男性特发性甲状旁腺功能减退症伴甲状腺乳头状癌：罕见病例报告
DOI：
10.3389/fendo.2020.569308
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发表时间：
2020
影响因子：
5.2
通讯作者：
Zhu J
中科院分区：
文献类型：
--
作者：
Chen W;Chen L;Wei T;Li Z;Lei J;Zhu J
特发性甲状旁腺功能减退症(IHP)是一种罕见的疾病，通过排除其他可能的病因来诊断。甲状腺手术约占所有甲状旁腺功能减退症的14-60%；其中，甲状腺乳头状癌(PTC)手术是最常见的原因。在此，我们报告一例非常罕见的IHP合并PTC病例。患者男，22岁，有无法控制的四肢无力、面部麻木、痉挛和抽搐9年的病史。他被误诊为癫痫，抗癫痫治疗没有得到缓解。实验室评估显示甲状旁腺激素和血钙降低，无机磷升高。考虑IHP后，超声在右侧甲状腺上极发现1个大小为13×8×9 mm的不规则形低回声实性结节，细针抽吸活检提示为PTC。然后，患者接受了手术治疗和放射性碘消融。长期治疗策略包括口服左旋甲状腺素以抑制促甲状腺激素，口服钙和维生素D补充剂以控制低钙血症。我们报告一位22岁男性罕见的IHP合并PTC病例。我们在治疗过程中的一些经验和教训值得讨论，希望我们的报告能为今后类似患者的诊断和治疗提供参考。
Idiopathic hypoparathyroidism (IHP) is a rare disorder that is diagnosed by excluding other possible etiologies. Thyroid surgery causes approximately 14–60% of all cases of hypoparathyroidism; of these, surgery for papillary thyroid carcinoma (PTC) is the most common reason. Here, we report an extremely rare case of IHP combined with PTC. A 22-year-old man presented with a history of uncontrollable extremity and facial numbness, spasm and twitch lasting for nine years. He had been misdiagnosed with epilepsy and gained no relief from antiepileptic therapy. The laboratory evaluation revealed reduced parathyroid hormone and serum calcium and elevated inorganic phosphorus. After considering IHP, ultrasound detected a solid hypoechoic and irregularly shaped nodule 13×8×9 mm in size in the upper pole of the right thyroid gland, and fine-needle aspiration biopsy indicated PTC. Then, the patient underwent surgical treatment and radioactive iodine ablation. The long-term treatment strategy consisted of oral levothyroxine for thyroid-stimulating hormone inhibition and oral calcium and vitamin D supplements for hypocalcemia control. We report a rare case of IHP combined with PTC in a 22-year-old male. Some experiences and lessons from our treatment procedure merit discussion, and we hope that our report can serve as a reference for the diagnosis and treatment of similar patients in the future.
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影响因子：
3.7
作者：
Kwak, Jin Young;Kim, Eun-Kyung;Nam, Kee-Hyun
通讯作者：
Nam, Kee-Hyun
影响因子：
3.7
作者：
Kim, Yehree;Roh, Jong-Lyel;Kim, Sang Yoon
通讯作者：
Kim, Sang Yoon
影响因子：
2.6
作者：
Lee, Yong Sang;Kim, Seok Won;Chung, Ki-Wook
通讯作者：
Chung, Ki-Wook
影响因子：
2.2
作者：
Chen, Qiang;Wei, Tao;Zhu, Jing-qiang
通讯作者：
Zhu, Jing-qiang
影响因子：
3
作者：
Colaco, Shanthi M.;Si, Ming;Clark, Orlo H.
通讯作者：
Clark, Orlo H.