Pathogenicity and virulence of Bordetella pertussis and its adaptation to its strictly human host.
Pathogenicity and virulence of Bordetella pertussis and its adaptation to its strictly human host.
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DOI：
10.1080/21505594.2021.1980987
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发表时间：
2021-12
期刊：
影响因子：
5.2
通讯作者：
Jacob-Dubuisson F
中科院分区：
文献类型：
--
作者：
Belcher T;Dubois V;Rivera-Millot A;Locht C;Jacob-Dubuisson F
高度传染性百日咳病原体百日咳博德特氏菌已经从一个祖先进化为人类限制性病原体，该祖先还产生了副百日咳博德特氏菌和支气管败血博德特氏菌。而后者殖民于广泛的哺乳动物，并能够在环境中生存，B。百日咳通过大规模的基因组衰退失去了在宿主外生存的能力。相反，它已经成为一个非常成功的人类病原体的收购严格管制的毒力因子和进化适应其代谢的特定生态位。通过部署高度复杂的毒力因子库，它克服了许多先天免疫防御。它还通过各种机制干扰疫苗诱导的适应性免疫。在这里，我们回顾了来自体外，人类和动物模型的数据，以说明适应人类呼吸道的机制，并提供证据证明正在进行的进化适应作为一个非常成功的人类病原体。
The highly contagious whooping cough agent Bordetella pertussis has evolved as a human-restricted pathogen from a progenitor which also gave rise to Bordetella parapertussis and Bordetella bronchiseptica. While the latter colonizes a broad range of mammals and is able to survive in the environment, B. pertussis has lost its ability to survive outside its host through massive genome decay. Instead, it has become a highly successful human pathogen by the acquisition of tightly regulated virulence factors and evolutionary adaptation of its metabolism to its particular niche. By the deployment of an arsenal of highly sophisticated virulence factors it overcomes many of the innate immune defenses. It also interferes with vaccine-induced adaptive immunity by various mechanisms. Here, we review data from in vitro, human and animal models to illustrate the mechanisms of adaptation to the human respiratory tract and provide evidence of ongoing evolutionary adaptation as a highly successful human pathogen.
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影响因子：
5.2
作者：
Antoine, Rudy;Rivera-Millot, Alex;Jacob-Dubuisson, Francoise
通讯作者：
Jacob-Dubuisson, Francoise
影响因子：
3.4
作者：
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通讯作者：
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影响因子：
3.7
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通讯作者：
Sebo, Peter
影响因子：
5
作者：
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通讯作者：
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影响因子：
3.7
作者：
Abramson T;Kedem H;Relman DA
通讯作者：
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