Mechanisms of Antibiotic Failure During Staphylococcus aureus Osteomyelitis.
Mechanisms of Antibiotic Failure During Staphylococcus aureus Osteomyelitis.
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DOI：
10.3389/fimmu.2021.638085
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发表时间：
2021
影响因子：
7.3
通讯作者：
Cassat JE
中科院分区：
文献类型：
--
作者：
Gimza BD;Cassat JE
金黄色葡萄球菌是一种非常成功的革兰氏阳性病原体，能够引起浅表性和侵入性的危及生命的疾病。在侵袭性疾病的表现中，骨髓炎或骨感染是最普遍的表现之一。金黄色葡萄球菌是最常见的病原体。骨髓炎的治疗是艰巨的，并且由于抗生素耐药菌株的广泛出现、葡萄球菌尽管起源于遗传易感背景但仍表现出对抗生素的耐受性的能力以及伴随感染的显著骨重塑和破坏而变得更加困难。因此，有必要更好地了解导致侵袭性葡萄球菌感染（如骨髓炎）抗生素治疗失败的因素。在这篇综述文章中，我们讨论了不同的非耐药机制的抗生素失败的S。金黄色。我们专注于细菌生态位和破坏性组织重塑如何影响抗生素疗效，生物膜形成在促进抗生素耐受性和持久性细胞形成，代谢静止的小菌落变体（SCV），以及骨亚结构内潜在的抗肿瘤保护水库的意义。
Staphylococcus aureus is a highly successful Gram-positive pathogen capable of causing both superficial and invasive, life-threatening diseases. Of the invasive disease manifestations, osteomyelitis or infection of bone, is one of the most prevalent, with S. aureus serving as the most common etiologic agent. Treatment of osteomyelitis is arduous, and is made more difficult by the widespread emergence of antimicrobial resistant strains, the capacity of staphylococci to exhibit tolerance to antibiotics despite originating from a genetically susceptible background, and the significant bone remodeling and destruction that accompanies infection. As a result, there is a need for a better understanding of the factors that lead to antibiotic failure in invasive staphylococcal infections such as osteomyelitis. In this review article, we discuss the different non-resistance mechanisms of antibiotic failure in S. aureus. We focus on how bacterial niche and destructive tissue remodeling impact antibiotic efficacy, the significance of biofilm formation in promoting antibiotic tolerance and persister cell formation, metabolically quiescent small colony variants (SCVs), and potential antibiotic-protected reservoirs within the substructure of bone.
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影响因子：
5.7
作者：
Fraunholz M;Sinha B
通讯作者：
Sinha B
DOI：
10.1016/j.nano.2017.11.006
发表时间：
2018-02-01
影响因子：
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作者：
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DOI：
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发表时间：
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期刊：
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
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影响因子：
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作者：
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影响因子：
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作者：
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