Decoupling of Global Brain Activity and Cerebrospinal Fluid Flow in Parkinson's Disease Cognitive Decline.
Decoupling of Global Brain Activity and Cerebrospinal Fluid Flow in Parkinson's Disease Cognitive Decline.
复制标题
帕金森病认知衰退中全球脑活动与脑脊液流动的解耦。
DOI：
10.1002/mds.28643
复制
发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Liu X
中科院分区：
文献类型：
--
作者：
Han F;Brown GL;Zhu Y;Belkin-Rosen AE;Lewis MM;Du G;Gu Y;Eslinger PJ;Mailman RB;Huang X;Liu X
错误折叠的蛋白质（α - 突触核蛋白和tau蛋白）的沉积和扩散与帕金森病的认知功能障碍有关。类淋巴系统可能通过脑脊液（CSF）在血管周围和间质空间的流动在清除这些毒性蛋白质方面发挥重要作用。近期研究发现，依赖睡眠的全脑活动与脑脊液流动相关，这可能反映了类淋巴系统的功能。
为了确定脑活动 - 脑脊液流动的解耦是否与帕金森病的认知功能障碍有关。
从60名帕金森病患者和58名对照受试者中收集了功能和结构磁共振成像数据、临床运动（统一帕金森病评定量表）以及认知（蒙特利尔认知评估，MoCA）评分。帕金森病患者被细分为有（MoCA < 26；N = 31）和无（MoCA ≥ 26；N = 29）轻度认知障碍（MCI）两组。对静息态全脑血氧水平依赖信号（gBOLD）与相关脑脊液流动之间的耦合强度进行了量化，在各组之间进行了比较，并与临床和结构测量结果相关联。
与无轻度认知障碍的帕金森病患者和对照组相比，有轻度认知障碍的帕金森病患者的gBOLD - CSF耦合显著降低（p < 0.006）。gBOLD - CSF耦合降低与蒙特利尔认知评估分数降低相关，这种相关性在帕金森病患者中存在（p = 0.005），但在对照组中不存在（p = 0.65）。帕金森病患者中较弱的gBOLD - CSF耦合还与右侧内嗅皮层变薄相关（斯皮尔曼相关性 = - 0.36；p = 0.012），这是一种在阿尔茨海默病中常见的早期结构变化。
全脑活动与相关脑脊液流动之间的解耦与帕金森病的认知障碍有关。
Deposition and spreading of misfolded proteins (α-synuclein and tau) have been linked to Parkinson’s cognitive dysfunction. The glymphatic system may play an important role in the clearance of these toxic proteins via cerebrospinal fluid (CSF) flow through perivascular and interstitial spaces. Recent studies discovered that sleep-dependent global brain activity is coupled to CSF flow that may reflect glymphatic function. To determine if the decoupling of brain activity-CSF flow is linked to Parkinson’s cognitive dysfunction. Functional and structural MRI data, clinical motor (Unified Parkinson’s Disease Rating Scale), and cognitive (Montreal Cognitive Assessment, MoCA) scores were collected from 60 Parkinson’s and 58 control subjects. Parkinson’s patients were sub-grouped into those with (MoCA < 26; N = 31) and without (MoCA ≥ 26; N = 29) mild cognitive impairment (MCI). The coupling strength between the resting-state global blood-oxygen-level-dependent signal (gBOLD) and associated CSF flow was quantified, compared among groups, and associated with clinical and structural measurements. gBOLD-CSF coupling decreased significantly (p < 0.006) in Parkinson’s patients showing MCI, compared to those without MCI and controls. Reduced gBOLD-CSF coupling was associated with decreased MoCA scores that was present in Parkinson’s patients (p = 0.005) but not in controls (p = 0.65). Weaker gBOLD-CSF coupling in Parkinson’s patients also was associated with a thinner right entorhinal cortex (Spearman’s correlation = − 0.36; p = 0.012), an early structural change often seen in Alzheimer’s. The decoupling between global brain activity and associated CSF flow is related to Parkinson’s cognitive impairment.
登录
查看更多内容
影响因子：
11.2
作者：
Goris, An;Williams-Gray, Caroline H.;Sawcer, Stephen J.
通讯作者：
Sawcer, Stephen J.
影响因子：
9.9
作者：
Dalrymple-Alford, J. C.;MacAskill, M. R.;Anderson, T. J.
通讯作者：
Anderson, T. J.
影响因子：
--
作者：
Fisher, RA
通讯作者：
Fisher, RA
影响因子：
2.5
作者：
Fukunaga, Masaki;Horovitz, Silvina G.;Duyn, Jeff H.
通讯作者：
Duyn, Jeff H.
影响因子：
5.7
作者：
Fischl, Bruce
通讯作者：
Fischl, Bruce