Rickettsial pathogen inhibits tick cell death through tryptophan metabolite mediated activation of p38 MAP kinase.
Rickettsial pathogen inhibits tick cell death through tryptophan metabolite mediated activation of p38 MAP kinase.
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人力车病原体通过色氨酸代谢物介导的p38 MAP激酶激活抑制tick细胞死亡。
DOI：
10.1016/j.isci.2022.105730
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发表时间：
2023-01-20
期刊：
影响因子：
5.8
通讯作者：
Neelakanta, Girish
中科院分区：
文献类型：
--
作者：
Namjoshi, Prachi;Dahmani, Mustapha;Sultana, Hameeda;Neelakanta, Girish
嗜吞噬细胞无形体调节哺乳动物细胞中多种细胞信号通路以维持其生存。在这项研究中，我们报告，A.嗜吞噬细胞菌调节蜱色氨酸途径以激活节肢动物p38 MAP激酶，从而使该细菌及其载体宿主存活。色氨酸代谢产物黄尿酸（XA）在A.嗜吞噬细胞菌感染的蜱和蜱细胞。A组细胞死亡标志物水平较低，总p38 MAPK和磷酸化p38 MAPK水平升高。嗜吞噬细胞菌感染的蜱和蜱细胞。XA处理增加了磷酸化p38 MAPK水平，减少了A.嗜吞噬细胞菌感染的蜱细胞。此外，用p38 MAPK抑制剂处理影响细菌复制，降低磷酸化p38 MAPK水平并增加蜱细胞死亡。然而，XA逆转了这些影响。总之，我们提供的证据表明，立克次体病原体调节节肢动物色氨酸和p38 MAPK途径，以抑制细胞死亡，其生存在蜱。嗜吞噬细胞无形体感染抑制蜱细胞死亡色氨酸代谢产物黄尿酸激活p38 MAPK。生物科学;分子生物学;微生物学;寄生虫学
Anaplasma phagocytophilum modulates various cell signaling pathways in mammalian cells for its survival. In this study, we report that A. phagocytophilum modulates tick tryptophan pathway to activate arthropod p38 MAP kinase for the survival of both this bacterium and its vector host. Increased level of tryptophan metabolite, xanthurenic acid (XA), was evident in A. phagocytophilum-infected ticks and tick cells. Lower levels of cell death markers and increased levels of total and phosphorylated p38 MAPK was noted in A. phagocytophilum-infected ticks and tick cells. Treatment with XA increased phosphorylated p38 MAPK levels and reduced cell death in A. phagocytophilum-infected tick cells. Furthermore, treatment with p38 MAPK inhibitor affected bacterial replication, decreased phosphorylated p38 MAPK levels and increased tick cell death. However, XA reversed these effects. Taken together, we provide evidence that rickettsial pathogen modulates arthropod tryptophan and p38 MAPK pathways to inhibit cell death for its survival in ticks. Anaplasma phagocytophilum infection inhibits tick cell death Tryptophan metabolite, xanthurenic acid, activates p38 MAPK Tick tryptophan and p38 MAPK pathways are critical for A. phagocytophilum survival Biological sciences; Molecular biology; Microbiology; Parasitology
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影响因子：
5.7
作者：
Cabezas-Cruz A;Espinosa PJ;Obregón DA;Alberdi P;de la Fuente J
通讯作者：
de la Fuente J
DOI：
10.1006/bbrc.1998.9327
发表时间：
1998-09-18
影响因子：
3.1
作者：
Fujita, T;Inoue, H;Maruyama, N
通讯作者：
Maruyama, N
影响因子：
2.4
作者：
Alberdi P;Espinosa PJ;Cabezas-Cruz A;de la Fuente J
通讯作者：
de la Fuente J
影响因子：
4.8
作者：
Kuma, Y;Sabio, G;Cuenda, A
通讯作者：
Cuenda, A
影响因子：
3.1
作者：
de la Fuente, Jose;Estrada-Pena, Agustin;Sonenshine, Daniel E.
通讯作者：
Sonenshine, Daniel E.