Metabolic syndrome and stroke recurrence in Chinese ischemic stroke patients--the ACROSS-China study.
Metabolic syndrome and stroke recurrence in Chinese ischemic stroke patients--the ACROSS-China study.
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DOI：
10.1371/journal.pone.0051406
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Investigators for the Survey on Abnormal Glucose Regulation in Patients with Acute Stroke Across China ACROSS-China
中科院分区：
文献类型：
--
作者：
Mi D;Jia Q;Zheng H;Hoff K;Zhao X;Wang C;Liu G;Wang Y;Liu L;Wang X;Wang Y;Investigators for the Survey on Abnormal Glucose Regulation in Patients with Acute Stroke Across China ACROSS-China
代谢综合征已成为心血管疾病的一个新的危险因素，因为它在基于人群的研究中预测中风的潜力。我们调查了代谢综合征与卒中复发的关系。这是一项对首次缺血性卒中后入组前瞻性急性卒中患者血糖调节异常（ACROSS-中国）研究的中国患者的回顾性分析。代谢综合征的定义采用国际糖尿病联合会（IDF）标准。评估血管风险因素。结果定义为缺血性卒中后一年内卒中复发。进行考克斯比例风险回归以确定卒中复发的潜在预测因子。2639例缺血性脑卒中患者中代谢综合征的患病率为51.35%。在一年的随访中，195例中风（7.4%）复发。代谢综合征组卒中复发的多变量风险比（95%CI）为1.94（1.39-2.73）。在调整成分后，代谢综合征失去了与卒中复发的相关性;在该模型中，高空腹血糖（IDF定义）是卒中复发的预测因子。对于中国缺血性脑卒中患者，代谢综合征可能不能预测卒中复发。
Metabolic syndrome has emerged as a novel risk factor in cardiovascular disease due to its potential for predicting stroke in population-based studies. We investigated the relationship of metabolic syndrome with stroke recurrence. This was a retrospective analysis of Chinese patients enrolled in the prospective Abnormal gluCose Regulation in patients with acute strOke acroSS China (ACROSS-China) study after their first ischemic stroke. Metabolic syndrome was defined using the International Diabetes Federation (IDF) criteria. Vascular risk factors were assessed. Outcome was defined as recurrence of stroke within one year after the index ischemic stroke. Cox proportional hazards regression was performed to identify potential predictors of stroke recurrence. The prevalence of metabolic syndrome among 2639 ischemic stroke patients was 51.35%. During the one-year follow-up, 195 strokes (7.4%) recurred. The multivariate hazard ratio (95% CI) of stroke recurrence was 1.94 (1.39–2.73) for metabolic syndrome. After adjustment for components, metabolic syndrome lost its association with stroke recurrence; in this model, high fasting plasma glucose (IDF definition) was a predictor for stroke recurrence. Metabolic syndrome may not be predictive for stroke recurrence beyond its component individual factors for Chinese ischemic stroke patients.
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影响因子：
8.3
作者：
Jia, Qian;Zhao, Xingquan;Wang, Yongjun
通讯作者：
Wang, Yongjun
影响因子：
8.3
作者：
Boden-Albala, Bernadette;Sacco, Ralph L.;Paik, Myunghee C.
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Paik, Myunghee C.
影响因子：
8.3
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Iso, Hiroyasu;Sato, Shinichi;Shimamoto, Takashi
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Shimamoto, Takashi
影响因子：
8.3
作者：
BROTT, T;ADAMS, HP;WALKER, M
通讯作者：
WALKER, M
影响因子：
5.1
作者：
Liou, C. -W.;Tan, T. -Y.;Yip, H. -K.
通讯作者：
Yip, H. -K.